Objective: We compared health outcomes in obese adults who underwent 12 wk of exercise counseling with or without dietary counseling, followed by 12 wk of observational monitoring.
Methods: Ninety adults (77 women and 13 men; 42.6 +/- 6.0 y; body mass index, 31.5 +/- 2.8 kg/m(2)) were randomly assigned to exercise-only (EX) or diet-plus-exercise (DEX) groups and counseled weekly by exercise physiologists on a 12-wk walking program. DEX subjects were also counseled by dietitians on a hypocaloric diet (-500 kcal/d). From weeks 12 to 24, subjects were monitored but not counseled. At weeks 0, 12, and 24, data collection included body composition (air displacement plethysmography), fitness (maximum oxygen consumption, 3-min step-test, and timed mile), plasma lipids, weight loss efficacy (Weight Efficacy Life-Style Questionnaire), quality of life (Medical Outcomes Study Health Survey-Short Form 36), and mood (Profile of Mood States).
Results: At 12 and 24 wk, weight and body mass index decreased in DEX subjects (both P < 0.05) but not in EX subjects. However, lean body mass increased significantly in EX (24 wk, P < 0.05) but not in DEX subjects. In both groups, fat mass decreased (P < 0.05 for EX subjects at 24 wk; P < 0.05 for DEX subjects at 12 and 24 wk) and waist circumference decreased (P < 0.05 for EX subjects at 12 and 24 wk; P < 0.05 for DEX subjects at 12 and 24 wk). At 12 and 24 wk, DEX subjects showed decreased levels of total plasma cholesterol and triacylglycerols (both P < 0.05) and improvements with regard to the Weight Efficacy Life-Style Questionnaire (P < 0.05), three domains of the Medical Outcomes Study Health Survey-Short Form 36 (all P < 0.05), and three domains of the Profile of Mood States (all P < 0.05) that were not seen in EX subjects.
Conclusions: Exercise counseling for 12 wk in obese adults improves some body composition indices that can be sustained over 12 wk of monitoring. The addition of dietary counseling increases improvements in body composition, lipid profiles, and several psychological parameters.
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http://dx.doi.org/10.1016/j.nut.2004.06.004 | DOI Listing |
BMC Nurs
December 2024
School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong Province, China.
Background: Post-Traumatic Growth (PTG) relieves physical and psychological stress symptoms in nurses who exposed to nurse-to-nurse horizontal violence (HV), has great intervention potential to reverse the negative effects of HV events. Therefore, in-depth exploration of the overall characteristics of PTG in HV-exposed nurses and its influencing factors are of great practical significance to provide them with precise psychological adaptive interventions.
Objective: This study aims to describe the current state of PTG of HV-exposed nurses and its influencing factors.
Front Pharmacol
November 2024
Phase I Clinical Trial Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Background: Intranasal administration is a convenient route for drug delivery that can be applied for procedural sedation. However, there is currently limited exploration into fixed dosing regimens. This study was to investigate the pharmacokinetics (PK), pharmacodynamics (PD), bioavailability (BA) and safety of dexmedetomidine after fixed doses of intranasal and intravenous administration in healthy male and female subjects.
View Article and Find Full Text PDFClin Oral Investig
December 2024
Faculty of Dentistry, Department of Periodontology, Van Yuzuncu Yil University, Van, Turkey.
Objective: The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone (DEX) on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery (PFS).
Methods: In this randomized controlled split-mouth study, 25 patients underwent PFS in the mandible, whereby postoperative, submucosal DEX was injected to the surgical field to the test group and submucosal normal saline was applied to the control group. Pain was evaluated using the Visual Analogue Scale (VAS) and the 101-point numeric rate scale in the first 8 h after PFS and on the 2nd, 3rd, 4th, and 7th days, whereas swelling, chewing efficiency, trismus, healing, discomfort and analgesic consumption were evaluated preoperatively on the 1st, 2nd and 7th days.
Cureus
October 2024
Department of Hematology, Japanese Red Cross Medical Center, Tokyo, JPN.
Chimeric antigen receptor T-cell (CAR-T) therapy targeting the B-cell maturation antigen (BCMA) is an effective treatment for patients with relapsed/refractory multiple myeloma (RRMM). However, cytokine release syndrome (CRS) represents a significant complication associated with CAR-T therapy. While most CRS cases involve systemic symptoms such as fever, hypotension, and respiratory distress, localized symptoms (referred to as local CRS) can also occur.
View Article and Find Full Text PDFPerioper Med (Lond)
October 2024
Department of Anesthesiology, Ambulatory Surgery Center, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, China.
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