Objective: To estimate the risk of dental caries in 5-7 year old Danish children who received prescriptions for asthma-drugs.
Design: Population-based cohort-study based on data from a prescription registry and dental database. Setting The County of North Jutland, Denmark.
Participants: 4,920 children born in 1993, and followed to the end of 2000. Main outcome measures Dental caries in primary canines and molars, and permanent teeth.
Results: Between the age 3 and 5 years 30.4% of the children received one or more prescriptions for asthma-drugs compared to 18.8% between 5 and 7 years of age. Children often received two or more drugs in combination. Approximately 6% of the children received both inhaled cortico-steroids and inhaled beta2-agonists between 3 and 7 years of age. No increased risk of caries could be shown in the primary teeth, while the relative risk of caries in the permanent teeth was estimated at 1.45 (95% C.I.: 0.99-2.11) in children who received prescriptions of both inhaled beta2-agonists and corticosteroids between 5 and 7 years. Of the 169 children who received prescriptions of both inhaled beta2-agonists and cortico-steroids between the ages of 3 and 7 years, the relative risk was estimated at 1.62 (95% C.I.: 1.03-2.56).
Conclusions: Asthma-drugs may increase the risk of caries in newly erupted permanent molars.
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