Fighting type 2 diabetes and its high risk of CVD, lifestyle intervention with diet and exercise is of uttermost importance. Epidemiological studies strongly suggest an inverse association between increased physical activity, moderate alcohol drinking and the incidence of both type 2 diabetes and CVD. However, alcohol is known to increase postprandial lipaemia, a risk marker of CVD, and exercise to reduce postprandial lipaemia in healthy individuals. The aim of the present study was to investigate how type 2 diabetic men respond, in the postprandial period, to a single exercise session feasible to perform on a daily basis for type 2 diabetic men. The twelve participants ingested a test meal containing 100 g butter, 50 g carbohydrate, together with 40 g alcohol, at each meal test, imitating a social meal situation. Two protocols included exercise sessions with 40 min at 40% VO2max, one where they exercised 3.5 h after, and another the afternoon before the test meal. One protocol was without any exercise. No significant effect of low-intensity exercise on postprandial lipaemia following a fat-rich meal with alcohol was seen in the middle-aged type 2 diabetic men.
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http://dx.doi.org/10.1079/bjn20041227 | DOI Listing |
J Am Nutr Assoc
January 2025
Department of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas - UNICAMP, Campinas, SP, Brazil.
A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants. We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.
View Article and Find Full Text PDFRes Sq
November 2024
Division of Endocrinology, Diabetes and Metabolism, New York University Grossman School of Medicine, New York, NY 10016.
The effect of increased triglycerides (TGs) as an independent factor in atherosclerosis development has been contentious, in part, because severe hypertriglyceridemia associates with low levels of low-density lipoprotein cholesterol (LDL-C). To test whether hyperchylomicronemia, in the absence of markedly reduced LDL-C levels, contributes to atherosclerosis, we created mice with induced whole-body lipoprotein lipase (LpL) deficiency combined with LDL receptor (LDLR) deficiency. On an atherogenic Western-type diet (WD), male and female mice with induced global LpL deficiency (i ) and LDLR knockdown ( ) developed hypertriglyceridemia and elevated cholesterol levels; all the increased cholesterol was in chylomicrons or large VLDL.
View Article and Find Full Text PDFNutr Res Rev
November 2024
Aix-Marseille University, INRAE, INSERM, C2VN, Marseille, France.
Lipids play an important role in human nutrition. Although adequate lipid consumption is necessary for an optimal functioning of the human body, overconsumption of saturated fatty acids can lead to postprandial hypertriglyceridaemia, which triggers the development of atherosclerosis. Important parameters that impact postprandial lipaemia and inflammation are related to the matrix structure and the fat-soluble micronutrient profile of ingested foods/lipids, but the specific effect of these parameters should be further studied, as most of the available studies evaluate their effect at fasting state.
View Article and Find Full Text PDFFront Physiol
September 2024
Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan.
Aims: High non-fasting triglycerides (TG) concentration is linked to the development of atherosclerosis, and physical activity is commonly recommended to reduce postprandial TG concentration and cardiovascular diseases. Previous studies have demonstrated that acute whole-body (walking and running) or lower-body (leg cycling) aerobic exercise reduces postprandial TG. However, it is unclear whether upper-body exercise (i.
View Article and Find Full Text PDFMol Nutr Food Res
November 2024
Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada.
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