Mannich-type C-nucleosidations in the 5,8-diaza-7,9-dicarba-purine family.

Org Lett

Laboratory of Organic Chemistry, Swiss Federal Institute of Technology, Hönggerberg, HCI-H309, CH-8093 Zürich, Switzerland.

Published: October 2004

[structure: see text] C-Nucleosidation with cyclic iminium salts occurring under mild reaction conditions and affording C-nucleosides that are isosteric with N-nucleosides of natural purines is shown to be a consistent property of the entire family of 2,6-(oxo or amino)-disubstituted 5,8-diaza-7,9-dicarba-purines.

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http://dx.doi.org/10.1021/ol048649mDOI Listing

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[structure: see text] C-Nucleosidation with cyclic iminium salts occurring under mild reaction conditions and affording C-nucleosides that are isosteric with N-nucleosides of natural purines is shown to be a consistent property of the entire family of 2,6-(oxo or amino)-disubstituted 5,8-diaza-7,9-dicarba-purines.

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