AI Article Synopsis
- Highly reactive zinc metal was produced through electrolysis of a N,N-dimethylformamide solution, enabling the transformation of ethyl 2-bromoacrylate into unique organozinc compounds.
- These organozinc compounds, not achievable with standard zinc, reacted efficiently with aryl halides using a palladium catalyst, leading to successful cross-coupling reactions.
- This method facilitated the synthesis of important pharmaceutical precursors, including those for anti-inflammatory drugs like ibuprofen and naproxen.
Article Abstract
Highly reactive zinc metal was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive electrogenerated zinc (EGZn/Naph) was used for transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compounds thus prepared with various aryl halides in the presence of 5 mol% of palladium catalyst gave the corresponding cross-coupling products in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursor of anti-inflammatory agents such as ibuprofen, naproxen, cicloprofen and suprofen.
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