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Safety and efficacy of low molecular weight dextran (dextran 40) in head and neck free flap reconstruction.
J Reconstr Microsurg
September 2013
Department of Head and Neck Surgery, Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Background: Antithrombotic agents have been used in microvascular surgeries. Low molecular weight dextran (dextran 40), though used, is not without complications.
Methods: Retrospective analysis of 172 consecutive flaps.
Dextran-related complications in head and neck microsurgery: do the benefits outweigh the risks? A prospective randomized analysis.
Plast Reconstr Surg
November 2003
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Increased experience with free-tissue transfer has minimized flap loss secondary to microvascular thrombosis, yet pharmacologic antithrombotic prophylaxis continues to be used routinely. Currently there is no consensus on the ideal pharmacologic agent, dosing, or efficacy. Low-molecular-weight dextran has been widely used for prophylaxis due to its properties of volume expansion and enhanced microrheology.
View Article and Find Full Text PDFFirst use of hypertonic saline dextran in children: a study in safety and effectiveness for atrial septal defect surgery.
Shock
November 2003
Division of Surgery, São Paulo University School of Medicine, São Paulo, Brazil 05403-900.
Hypertonic saline dextran (7.5% NaCl + 6% Dextran-70) has been used in adults in several studies and shown beneficial effects in hypovolemic shock, trauma, cardiogenic shock, and cardiac surgery. There have never been studies of this solution in children.
View Article and Find Full Text PDFDextran syndrome. Acute hypotension, noncardiogenic pulmonary edema, anemia, and coagulopathy following hysteroscopic surgery using 32% dextran 70.
Chest
February 1997
Division of Internal Medicine, Evertt Clinic, Wash, USA.
Dextran solutions are favored distending media for many hysteroscopic procedures because they are easy to administer, distribute uniformly within the uterine cavity, and are relatively nontoxic. We present the case of a 26-year-old woman who developed hypotension, noncardiogenic pulmonary edema, and hemorrhagic diathesis following hysteroscopic surgery with 32% dextran 70. A medical literature review indicates that following hysteroscopic surgery in which dextran solution has been used, "dextran syndrome" has been diagnosed in some patients.
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