AI Article Synopsis
- The study examines three methods (mixing, absorption, and a combination of both) for preparing drug-loaded microcapsules using alginate, poly-L-arginine, and chitosan.
- The absorption method significantly increases drug loading, achieving a maximum drug load of 19.9% and an encapsulation efficiency of 93.8% when combined with mixing.
- Different methods affect drug release kinetics, with mixing yielding zero-order kinetics, absorption resulting in first-order kinetics, and the combined method showing a transition from first-order to zero-order kinetics after 18 hours.
Article Abstract
The drug-loaded alginate/poly-L-arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug-loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero-order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first-order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first-order kinetics during the first eighteen hours, changing afterwards to a zero-order kinetics process. Effect of drug-loading methods on drug load and encapsulation efficiency of alginate/poly-L-arginine/chitosan ternary complex microcapsules.
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| http://dx.doi.org/10.1002/mabi.200300043 | DOI Listing |
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