Modern anthelmintic use in horses has decreased the prevalence of the large strongyles, which has in turn shifted the focus of parasitologists to the pathogenic importance of the small strongyles, tapeworms, and other parasites. These studies show that a combination product containing ivermectin and praziquantel allowed efficacious treatment of horses for nematode, cestode, and bot infections. The use of this combination product may be of special benefit to horses that are mainly kept outdoors and on grazing pastures.

Download full-text PDF

Source

Publication Analysis

Top Keywords

ivermectin praziquantel
8
combination product
8
antiparasitic activity
4
activity ivermectin
4
praziquantel combination
4
combination paste
4
horses
4
paste horses
4
horses modern
4
modern anthelmintic
4

Similar Publications

Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions.

Inflammopharmacology

November 2024

Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí (UFPI), Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil.

Acute, uncontrolled and/or long-lasting inflammation causes a breakdown in immunological tolerance, leading to chronicity and contributing to a series of significant local or systemic tissue changes. Anti-inflammatory efficacy, fewer adverse effects, improved selectivity, and curative action are imminent issues for patients suffering from chronic inflammation-related pathologies. Then, we performed a complete and critical review about anthelmintics, discussing the main classes and the available preclinical evidence on repurposing to treat inflammation-based conditions.

View Article and Find Full Text PDF

Introduction: Tropical climates in remote Aboriginal and Torres Strait Islander communities in northern Australia are conducive to the transmission of canine helminths such as hookworms, as well as ectoparasites such as fleas and ticks. In addition to their veterinary importance, these parasites may present a zoonotic risk either directly, or as potential vectors for bacterial pathogens. These factors necessitate efficacious and effective antiparasitic treatment programs for community dogs.

View Article and Find Full Text PDF

Purpose: Currently, for veterinary oral formulations containing one or more active pharmaceutical ingredient (API) that are not systemically absorbed and act locally within the gastrointestinal (GI) tract, the use of terminal clinical endpoint bioequivalence (BE) studies is the only option for evaluating product BE. This investigation explored the use of a totality of evidence approach as an alternative to these terminal studies.

Methods: Three formulations of tablets containing ivermectin plus praziquantel were manufactured to exhibit distinctly different in vitro release characteristics.

View Article and Find Full Text PDF
Article Synopsis
  • * A study tested the effectiveness of NexGard Combo, a topical treatment for cats, against these ticks by using a controlled group of cats—half received treatment while the other half did not.
  • * Results showed a 98.7% efficacy in eliminating existing ticks within 72 hours of treatment and a preventive efficacy ranging from 93.8% to 99.4% during subsequent weekly infestations over five weeks.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness of a spot-on treatment called NexGard® Combo, containing eprinomectin, esafoxolaner, and praziquantel, for treating respiratory diseases in cats caused by metastrongyloids Aelurostrongylus abstrusus and Troglostrongylus brevior.
  • Conducted with 36 infected cats divided into two groups, the treatment regimen involved administering the medication on specified study days while monitoring parasitological, clinical, and radiographic changes.
  • Results showed 100% efficacy in reducing larval shedding in cats with single infections and significant clinical improvement in all cats after two treatments, highlighting the treatment's effectiveness against the parasites.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!