The Minimal Model method of determining Insulin Sensitivity from the Intravenous glucose Tolerance Test is a valuable tool for the Diabetes research community. However the Minimal Model algorithm itself is not readily available in a user-friendly modem windows environment to the clinical researcher in many research departments. In addition use of the model often requires intervention by an experienced "modeller" to interpret the results produced by the method. This paper proposes a more readily available and usable version of the program and discusses the issues which surround the use of the program by clinical researchers without computer mathematical modelling experience.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Aggregation-Induced Photosensitization of Long-Chain-Substituted Osmium Complexes for Lysosomes Targeting Photodynamic Therapy.
ACS Appl Bio Mater
March 2025
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.
Photodynamic therapy (PDT) has been demonstrated to be an effective tool for cancer treatment. Seeking organelle-targeting photosensitizers (PSs) with robust reactive oxygen species (ROS) production is extremely in demand. Herein, we propose an aggregation-induced photosensitization strategy for effective PDT with osmium complexes.
View Article and Find Full Text PDFScale-up of a low-temperature spray-drying process for a tuberculosis vaccine candidate using lab-scale equipment.
Int J Pharm
March 2025
Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Laboratory-scale spray drying can be a useful tool in developing new dry powder formulations for the delivery of biologics such as therapeutic proteins or vaccines. Low-temperature drying is often used in these processes to prevent the exposure of biologics to harsh conditions that could potentially lead to degradation or instability of the final product. However, low-temperature drying on small-scale equipment can result in very low production rates that may not be practical for generating sufficient material for studies requiring larger sample quantities, such as key preclinical or toxicology studies.
View Article and Find Full Text PDFRisk and Dose-Response Relationship for Pentosan Polysulfate Sodium Maculopathy: A Systematic Review and Meta-Analysis.
Ophthalmol Retina
March 2025
Department of Ophthalmology & Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:
Topic: To determine the pooled relative risk (RR) of Pentosan Phosphate Sodium Maculopathy (PPSM) in patients using PPS and model the dose-response relationship of this association from existing literature.
Clinical Relevance: PPSM is an acquired, progressive retinal pigmentary disease associated with oral PPS use. Though several observational studies suggest a dose-response relationship of this association, to-date, there remains no literature-pooled synthesis on risk of PPSM across strata of cumulative dose.
Preclinical evaluation of several polymeric micelles identifies Soluplus®-docetaxel as the most effective candidate in multiple glioblastoma models.
J Control Release
March 2025
Clinical Biochemistry, Drug Delivery and Therapy Group (CB-DDT), Vall d'Hebron Institut of Research (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Passeig de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain; Functional Validation & Preclinical Research (FVPR)/U20 ICTS Nanbiosis, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology and Physicochemistry, Faculty of Pharmacy and Food Sciences, School of Pharmacy, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain. Electronic address:
Glioblastoma multiforme (GBM) is one of the most lethal cancers, with limited treatment options due to the blood-brain barrier (BBB), systemic toxicity, and treatment resistance. Nanomedicine offers potential solutions to these challenges. This study explores Pluronic® F127 and Soluplus®-based micelles as carriers for Lomustine, Gefitinib, and Docetaxel to determine the optimal system for GBM therapy.
View Article and Find Full Text PDFEstimation of inlet flow rate in simulations of left atrial flows: A proposed optimized and reference-based algorithm with application to sinus rhythm and atrial fibrillation.
J Biomech
March 2025
Department of Computational Physiology, Simula Research Laboratory, Kristian Augusts gate 23, 0164 Oslo, Norway. Electronic address:
Medical image-based computational fluid dynamics (CFD) is a valuable tool for studying cardiovascular hemodynamics and its role in vascular pathologies. However, patient-specific flow rate measurements are rare. As a remedy, individual flow rates are typically estimated using anatomical features.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!