New stilbene (CAS 56-53-1) derivatives have been synthesized by reductive elimination of desoxybenzoin analogs which were obtained by Fries rearrangement of the corresponding phenolic esters. The chemical structures of the compounds obtained were confirmed by 1H-NMR, IR and elemental analysis. Anti-implantation activity of the compounds was determined by performing experiments with adult male and female Spargue-Dawley rats of proven fertility. A 67% inhibition of implantation was observed separately with compounds 3f and 3i.
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View Article and Find Full Text PDFPhytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of leaves.
J Complement Integr Med
December 2024
National Forensic Sciences University, Ponda, Goa, India.
Article Synopsis
- The study aimed to investigate the molecular docking characteristics and antifertility effects of extracts derived from PO leaves, specifically petroleum ether and chloroform extracts.
- Using molecular docking software and animal models, researchers found that the petroleum ether extract (PEEPO) had a stronger anti-implantation effect than the chloroform extract (CHEPO) at various doses.
- The results suggested that both extracts are safe at high dosages, increase blood estrogen levels, and interact favorably with estrogen receptors, indicating their potential for developing herbal antifertility treatments.
Anti-fertility effect of crude extract in male Dams offspring: An experimental study.
Int J Reprod Biomed
March 2023
Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo State, Laje Campus, Ondo City, Ondo State, Nigeria.
Background: a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities.
Objective: This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of .
A Brief Review on (Orange Jasmine): pharmacognosy, phytochemistry and ethanomedicinal uses.
J Pharmacopuncture
March 2023
Department of Pharmacology, Anand College of Pharmacy, Agra, Uttar Pradesh, India.
Objectives: (family-Rutaceae), popularly known as orange jasmine, is the most important evergreen plant. The Rutaceae family is economically significant due to its diverse edible fruits and essential oils.
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Mifepristone increases AQP1 mRNA expression, angiogenesis, and cell permeability through the ERK MAPK pathway.
Mol Biol Rep
February 2023
Department of Pathology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, China.
Aims: The purpose of this study was to investigate the mechanism of mifepristone serves as an anti-implantation contraceptive drug on aquaporins 1 (AQP1) expression.
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