[Changes of intracellular calcium-regulating mechanisms of primary and secondary sensory neurones in periferal inflammation].

Here we summarize the results of experimental investigation of changes in intracellular calcium homeostasis in mice and rat primary (dorsal root ganglia, DRG) and secondary (dorsal horn, DH) sensory neurons under carrageenan-induced periferal inflammation. A decrease in a calcium accumulation in both inositoltriphosphate- and caffeine-sensitive endoplasmic reticulum calcium stores has been detected in primary sensory neurons under condition of peripheral inflammation. We have also shown a decrease in the caffeine-induced calcium release in dorsal horn neurons of inflamed rat as compared to control ones. Decrease in the Ca2+ -accumulating properties of mitochondria has been demonstrated in both DRG and DH neurons with carrageenan-induced inflammation as compared with neurons of control animals. We conclude that changes in Ca2+ -regulating structures of primary and secondary sensory neurons could possibly lead to alterations in the transmission of nociceptive signals during inflammation.