The aim of this study was to describe how the Boston brace modify the scoliotic curvatures using a finite element (FE) model and experimental measurements. The experimental protocol, applied on 12 scoliotic girls, was composed of the pressure measurement at the brace-torso interface followed by two radiographic acquisitions of the patient's torso with and without brace. A 3D FE model of the trunk was built for each unbraced patient. The brace treatment was represented by two different modeling approaches: 1) using equivalent forces calculated from the measured pressures; 2) by an explicit personalized FE model of the brace (hexahedral elements) and its interface with the torso (contact elements). In the first model, measured brace forces less than 40N and up to 113N induced respectively less than 21% and up to 87% of real correction. Thoracic forces induced the main correction, affecting partially both lumbar and thoracic curves, in agreement with the literature. In the second model, the brace closing reduced the curves up to 35% of real correction. Contact reaction forces (16-79N) were similar to real brace forces (11-72N). The results suggested that other mechanisms than brace pads contribute to the equilibrium of the patients. Postural control by the muscular system remains a problem to address in a future study. The second model represented more realistically the load transfer from the brace to the spine than external forces application. With such model, it is expected to predict the effect of a brace before its design and manufacturing, and also to improve its design.
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World J Gastrointest Surg
January 2025
Department of General Surgery, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, China.
Background: Malignant obstructive jaundice (MOJ) is characterized by the presence of malignant tumors infiltrating or compressing the bile duct, causing poor bile drainage, generalized yellowing, pain, itching, and malaise. MOJ is burdensome for both the society and the families of affected patients and should be taken seriously.
Aim: To evaluate the clinical effect of stent placement during endoscopic retrograde cholangiopancreatography for relieving MOJ and the efficacy of percutaneous transhepatic biliary drainage in terms of liver function improvement, complication rates, and long-term patient outcomes.
Clin Transl Immunology
January 2025
Infectious Diseases Group, Infection, Immunity and Global Health Theme Murdoch Children's Research Institute Parkville VIC Australia.
Objectives: Bacille Calmette-Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune responses to vaccines against SARS-CoV-2.
Methods: Blood samples, from a subset of 275 SARS-CoV-2-naïve healthcare workers randomised to BCG vaccination (BCG group) or no BCG vaccination (Control group) in the BRACE trial, were collected before and 28 days after the primary course (two doses) of ChAdOx1-S (Oxford-AstraZeneca) or BNT162b2 (Pfizer-BioNTech) vaccination.
BMC Musculoskelet Disord
January 2025
Scientific Institute, I.R.C.C.S. "E.Medea", Bosisio Parini, Italy.
Objective: Spinal orthoses are the most viable conservative treatment for scoliosis, and additive manufacturing techniques have shown huge perspective in producing patient-specific braces, reducing material waste, and production times. This pilot study aimed at determining whether 3D-printed braces could induce advantages or disadvantages compared to conventional braces in terms of mobility and gait, and at quantitatively evaluating the effects of braces on mobility and gait.
Methods: Ten participants were included in the study, eight with adolescent idiopathic scoliosis and two with osteogenesis imperfecta.
J Am Podiatr Med Assoc
January 2024
‖Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Orthop J Sports Med
January 2025
Pan Am Clinic and University of Manitoba, Winnipeg, Manitoba, Canada.
Background: Inconsistencies in the workup of labral tears in the hip have been shown to result in a delay in treatment and an increased cost to the medical system.
Purpose: To establish consensus statements among Canadian nonoperative/operative sports medicine physicians via a modified Delphi process on the diagnosis, nonoperative and operative management, and rehabilitation and return to play (RTP) of those with labral tears in the hip.
Study Design: A consensus statement.
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