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Low serum S100A6 levels are associated RP-ILD risk in anti-MDA5-positive dermatomyositis.
Clin Rheumatol
December 2024
Division of Rheumatology, Northern Jiangsu People's Hospital, Jiangsu, China.
Introduction: Anti-MDA5-positive dermatomyositis (anti-MDA5-DM) is a rare autoimmune disease that often leads to rapid-progressive interstitial lung disease (RP-ILD). The lack of effective prediction and treatment methods makes RP-ILD a major risk factor for death in patients with this condition. S100A6 is a member of the S100 Ca2 + - binding protein family, which plays important roles in inflammation, tumor, injury, and fibroblast reparation.
View Article and Find Full Text PDFPneumocystis jirovecii pneumonia increases the 3-months mortality of anti-MDA5-antibody-positive dermatomyositis patients.
Front Immunol
December 2024
Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+DM) patients are associated with considerable mortality, and opportunistic infections including Pneumocystis jirovecii pneumonia (PJP)is the main cause. This study was to identify clinical characteristics, risk factors, and prognostic factors of PJP diagnosed by bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) in anti-MDA5+ DM patients.
Methods: In this retrospective observational study, all patients admitted with suspected pneumonia were detected for mNGS in BALF.
Panniculitis in dermatomyositis: A systematic review of the clinicopathologic features.
JAAD Int
February 2025
Division of Dermatology, Department of Medicine, The University of the West Indies, Mona Campus, Kingston, Jamaica.
Background: Panniculitis in patients with dermatomyositis (PDMS) is rare.
Objectives: Assess the clinicopathologic features described for PDMS.
Methods: A systematic review of the PubMed/MEDLINE database was performed.
A novel mouse model of myositis-associated interstitial lung disease was established by using TLR9 agonist combined with muscle homogenate.
Clin Exp Immunol
November 2024
Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, China.
Our group previously demonstrated that NETs were involved in interstitial lung diseases (ILD) among patients with idiopathic inflammatory myopathies (IIM) and the experimental autoimmune myositis (EAM) mouse model, and that NETs activated lung fibroblasts through the TLR9-miR7-Smad2 axis. This study aimed to establish a novel mouse model of myositis-associated interstitial lung disease (MAILD) by using a TLR9 agonist (ODN2395). ODN2395 and muscle homogenate were used to induce MAILD in BALB/c mice.
View Article and Find Full Text PDFImmune-Related Genes Associated with Interstitial Lung Disease in Dermatomyositis.
Int J Gen Med
November 2024
Department of Rheumatology, the Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Background: Interstitial lung disease (ILD) is one of the significant complications of dermatomyositis (DM), but the mechanisms by which it occurs remain incompletely elucidated. This study aimed to explore further the possible genetic mechanisms by which this complication occurs.
Methods: Gene expression profiles for DM (GSE39454, GSE46239, GSE143323) and ILD (GSE32537, GSE110147, GSE150910) were downloaded from the Gene Expression Omnibus (GEO) database.
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