One case of severe canine onychomycosis is described. The aetiological agent was identified as Microsporum gypseum. The incidence of this fungus in this kind of pathology is discussed, with special attention to the successful treatment with topic enilconazole and systemic griseofulvin.
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APMIS
January 2025
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)-derived halogenated furanones, which act to block the QS pathway, against key fungal pathogens of the skin (Candida albicans, Malassezia furfur and Microsporum gypseum). Moreover, we aimed to assess how these actives performed against complex interkingdom biofilms in a clinically relevant model.
View Article and Find Full Text PDFCurr Med Mycol
May 2024
Department of Mycology and Parasitology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Background And Purposes: The fungi known as dermatophytes are a group of keratinophilic agents responsible for superficial infections in humans and animals. Recognition of the species distribution and epidemiology of dermatophytosis may be helpful in the prevention and improve prophylactic measures. The present molecular epidemiology study sought to investigate the incidence of etiological agents causing dermatophytosis.
View Article and Find Full Text PDFEnferm Infecc Microbiol Clin (Engl Ed)
December 2024
UMAE Hospital de Pediatria CMN Occidente, IMSS, Zapopan, Jalisco, Mexico.
Background: Dermatophytosis caused by Nannizzia gypsea are considered rare. The clinical picture is indistinguishable from that produced by other dermatophytes, but, being this a geophilic fungus, it can cause more inflammatory disease.
Methods: Retrospective study.
J Invest Dermatol
December 2024
Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), National Scientific and Technical Research Council (CONICET), Córdoba, Argentina. Electronic address:
Fungal skin infections significantly contribute to the global human disease burden, yet our understanding of cutaneous immunity against dermatophytes remains limited. Previously, we developed a model of epicutaneous infection with Microsporum canis in C57BL/6 mice, which highlighted the critical role of IL-17RA signaling in antidermatophyte defenses. In this study, we expanded our investigation to the human pathogen Nannizzia gypsea and demonstrated that skin γδTCR and CD8/CD4 double-negative βTCR T cells are the principal producers of IL-17A during dermatophytosis.
View Article and Find Full Text PDFInt J Med Mushrooms
December 2024
Laboratory of Fungal Biology and Biotechnology, Yerevan State University, Yerevan, Armenia; Department of Cardiology, Clinic of General and Invasive Cardiology, University Hospital No. 1, Yerevan State Medical University, Yerevan, Armenia.
The study of antimicrobial activity (AMA) of 14 genetically identified dikaryotic strains of red belted medicinal polypore Fomitopsis pinicola isolated from Betula sp. and other deciduous trees, as well as conifers Picea sp. and Abies alba in Russia, France and Italy against test fungi and bacteria is discussed.
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