AI Article Synopsis
- Research identified substituted arylsulfoanilides as potential antiproliferative agents, showing effectiveness against lung cancer cells through intracellular Ca(2+) store depletion.
- The study found that certain substitution patterns on the arylsulfoanilides boosted their activity, leading to the creation of a hybrid compound, 27, combining arylsulfoanilide and 3-phenyloxindole.
- Compound 27 functions by inhibiting cancer cell growth through two mechanisms: reducing intracellular Ca(2+) stores and phosphorylating eIF2alpha.
Article Abstract
Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca(2+) stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca(2+) stores and phosphorylation of eIF2alpha.
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| http://dx.doi.org/10.1021/jm0496234 | DOI Listing |
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