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Q fever diagnosed using metagenomic next-generation sequencing in Guangdong Province, China.
Biosaf Health
December 2024
Institute of Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Q fever is a zoonotic disease caused by infection with (). Due to its atypical symptoms and the absence of specific detection methods, Q fever is underdiagnosed commonly. Herein, we report a case of Q fever confirmed by metagenomic next-generation sequencing (mNGS) in March 2024 in Guangdong Province, China.
View Article and Find Full Text PDFMonte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia.
Front Cell Infect Microbiol
March 2025
Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Objective: This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the efficacy in patients receiving continuous renal replacement therapy (CRRT). The goal was to optimize clinical dosing regimens and guide rational polymyxin B use in practice.
Methods: A total of 1,939 Gram-negative bacterial strains were analyzed, collected between April 2019 and December 2021 through the China Bloodstream Gram-negative Pathogens Antimicrobial Resistance and Virulence Surveillance Network (CARVIS-NET).
Study on the predictive value of preoperative CT features for the mitotic index of GIST based on the nomogram.
Sci Rep
March 2025
Department of Gastroenteropancreatic & Hernia Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Shanxi, 030012, China.
This study aimed to construct a Nomogram based on preoperative CT features to predict the mitotic index in gastrointestinal stromal tumors and to establish preoperative risk stratification. The constructed nomogram prediction model is targeted towards guiding preoperative risk stratification, facilitating the provision of rational drug administration regimens, and tailoring appropriate surgical plans for personalized treatment. The imaging and pathological data of 250 patients with gastrointestinal stromal tumors in Shanxi Provincial hospital from January 2019 to January 2024 were retrospectively analyzed.
View Article and Find Full Text PDFBackground: The purpose of the study was to understand the distribution and drug resistance characteristics of Enterococcus so as to provide a reliable basis for clinical use of antibiotics and hospital infection control.
Methods: In total, 3,455 strains of Enterococcus, isolated from January 2010 through December 2021, were col-lected. Bruker MALDI biotyper, MICROSCAN walkaway 40 analysis system, and Vitek-2 compact automatic drug sensitivity identification analyzer were used to identify the strains and to test drug sensitivity, and then the results were analyzed.
Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial.
JMIR Res Protoc
March 2025
Department of Cardiology, Life Bay View Private Hospital, Mossel Bay, South Africa.
Background: Chronic heart failure has high morbidity and mortality, with approximately half of the patients dying within 5 years of diagnosis. Recent additions to the armamentarium of anti-heart failure therapies include angiotensin receptor-neprilysin inhibitors (ARNIs) and sodium/glucose cotransporter 2 inhibitors (SGLT2is). Both classes have demonstrated mortality and morbidity benefits.
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