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Diagnostic utility of ERG immunostaining in dermatofibroma.
J Clin Pathol
August 2023
Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
Article Synopsis
- The study investigates the role of the ERG protein in diagnosing dermatofibroma/fibrous histiocytoma (DF/FH), a common benign skin tumor.
- Researchers analyzed a total of 97 cases of ordinary DF/FH along with various other types of skin neoplasms to assess ERG's immunohistochemical expression.
- Results showed high ERG positivity in DF/FH, suggesting its potential utility in differentiating DF/FH from dermatofibrosarcoma protuberans (DFSP).
Expression and Significance of AQP3 in Cutaneous Lesions.
Anal Cell Pathol (Amst)
March 2022
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.
Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry.
View Article and Find Full Text PDFMultiple stage tissue expansion for reconstruction of scalp nevocellular nevus in pediatric age group.
GMS Interdiscip Plast Reconstr Surg DGPW
April 2019
Department of Plastic Surgery and Burn Unit, King Fahad University Hospital, AlKhobar, Saudi Arabia.
To present a rare case of giant congenital nevocellular nevus in a 7-year-old girl's scalp and to highlight our management steps and outcomes. An otherwise healthy 7-year-old girl presented to plastic surgery clinic with a giant congenital nevus (GCN) that covered almost her entire scalp that was treated successfully with tissue expander three times over a period of 14 months. A total of 34 cm width of skin, which comprised 78% of the patient's scalp, was removed.
View Article and Find Full Text PDFMolecular profiling of Spitz nevi identified by digital RNA counting.
Melanoma Res
December 2018
Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center.
The molecular properties of benign melanocytic lesions are poorly understood. Only a few studies have been carried out on specific nevi subtypes, including common nevocellular nevi (NCN) or Spitz nevi (SN). Genomic alterations in melanoma-associated oncogenes are typically absent in SN.
View Article and Find Full Text PDFClinical and Pathological Analysis of Two Cases of Cutaneous Malignant Melanoma.
Curr Health Sci J
March 2015
Pathology dept., Clinical Emergency County Hospital of Craiova.
The purpose of this study was the clinical and histo-immunohistochemical analysis of two cases: a cutaneous pigmented facial malignant melanoma and a lumbar congenital nevus with malignant transformation. A series of clinical elements raised the suspicion of some malignant melanocytic lesions and the histopathological analysis through the paraffin embedding technique confirmed the clinical suspicion. The immunohistochemical analysis using the streptavidin-biotin-peroxydase method of the facial malignant melanoma showed: S100 protein intense and diffuse positive, Tyrosinase diffuse positive, HMB45 strong and focal positive, Cyclin D1 positive in approximately 40% and Ki-67 positive in almost 70% of the tumor cells.
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