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The authors report a case of intralobar pulmonary sequestration diagnosed accidentally in a 64-year-old woman. The patient subsequently underwent surgery. The authors were prompted by this fairly rare case to describe and discuss its anatomopathological, clinical, diagnostic and therapeutic aspects.
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J Assoc Physicians India
March 2025
Senior Consultant, Department of Medicine, Sir Ganga Ram Hospital, Delhi, India.
A man in his early 60s, with a history of obstructive airway disease and hypertension, had a fall from a height 1 year ago. He developed a fracture of the left distal tibia and fibula, for which open reduction and internal fixation (ORIF) was done. Since then, he has had persistent pain and discharge from the implant site, for which multiple antibiotics were given and debridement was done numerous times.
View Article and Find Full Text PDFTurk J Pediatr
February 2025
Department of Pediatric Surgery, Faculty of Medicine, Bursa Uludağ University, Bursa, Türkiye.
Background: Congenital lung malformations (CLMs) refer to structural abnormalities of the lungs that occur during fetal development. Matrix metalloproteinases (MMPs) constitute a group of zinc-dependent enzymes, with certain members of this family playing pivotal roles in the remodeling of the lungs both prenatally and postnatally. This study aimed to explore expression levels of MMP-2, MMP-7, and MMP-9 in CLMs which are recognized as pivotal contributors to their clinical pathology.
View Article and Find Full Text PDFJ Pediatr Clin Pract
March 2025
Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT.
Objective: To assess the incidence and clinical outcomes of neonates with congenital diaphragmatic hernia with patients with concurrent bronchopulmonary sequestration (CDH + BPS).
Study Design: In this retrospective cohort study, we compared BPS diagnoses in patients with CDH across 4 epochs (2002-2008, 2009-2015, 2016-2019, 2020-2023) to assess incidence and outcomes of neonates with CDH + BPS. Because of marked epoch differences in key outcomes, we only compared extracorporeal membrane oxygenation use and survival for CDH + BPS and CDH alone across the final 2 epochs using multinominal regression analysis.
Ital J Pediatr
March 2025
Pediatric Pulmonology & Cystic Fibrosis Unit, Respiratory Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Introduction: Children with congenital lung disease (CLD) may suffer from long-term complications, such as impairments in lung growth, decreased total lung volume, recurrent lower respiratory tract infections and, in some cases, malignant transformation.
Objective And Methods: we described retrospective data on diagnostic process, clinical and functional data regarding a cohort of symptomatic and asymptomatic children with CLD followed in a single third level center in the last twenty years.
Results: 91 children were included in the study.
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung, including congenital pulmonary airway malformations, bronchopulmonary sequestration (BPS), congenital lobar overinflation, bronchogenic cyst, and isolated congenital bronchial atresia. CLMs occur in 4 out of 10,000 live births. BPS can be intralobar or extralobar sequestration.
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