Aims: The present study was designed to (a) examine the interrelationship between endothelial function and CRP in healthy individuals and (b) evaluate the relationship of each biomarker towards global Framingham risk scores.
Methods And Results: Brachial artery flow-mediated vasodilatation (FMD), CRP, and traditional cardiovascular risk factors were measured in the Firefighters and Their Endothelium (FATE) study, which recruited 1154 male participants (mean age 47.4+/-9.8 years) with no known history of cardiovascular disease. No relationship was observed between FMD and CRP (p = 0.96). FMD and the Framingham risk score tended to correlate but not significantly (p = 0.07). A lower FMD was related to a higher systolic and diastolic blood pressure (p < 0.001 and p = 0.002, respectively) in the univariate analysis, and higher systolic blood pressure (p = 0.001) in the multivariate analysis. Elevated CRP levels independently correlated most closely with overall Framingham risk score (r = 0.36, p < 0.001) and a weaker although statistically significant relationship was seen with individual traditional cardiovascular risk factors (p < 0.005).
Conclusions: The current study provided evidence that brachial artery FMD had no relationship to CRP in a large cohort of healthy subjects. These observations suggest that the predictive value of CRP may be largely independent of abnormalities in endothelial function. The additive prognostic value of endothelial vasodilator testing remains to be established.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ehj.2004.06.039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Very Rare Presentation of Open Dislocation of the Elbow in a Child: A Case of Total Section of Brachial Artery and Present Distal Pulse with Literature Review.
Rev Bras Ortop (Sao Paulo)
November 2024
Departamento de Cirurgia Vascular, Faculdade de Medicina e Farmácia de Agadir, Ibn Zohr University, Agadir, Marrocos.
Open elbow dislocation is a rare emergency in children. Its association with brachial artery injury is very rare. We report the case of a child admitted for total section of the brachial artery on open dislocation of the elbow before absence of signs of ischemia of the upper limb concerned as well as a review of the literature which is very poor.
View Article and Find Full Text PDFA novel and alternative treatment method for moderate diabetic foot ulcer: tibial periosteal distraction.
J Orthop Surg Res
December 2024
Diabetic Foot Treatment Centre, Peking University People's Hospital, Peking University, Beijing, China.
Objective: Researchers have proposed a novel surgical treatment for moderate diabetic foot ulcer: tibial periosteal distraction (TPD) which could improve affected limb microcirculation. We aimed to describe the method and therapeutic effects of this technique.
Methods: We provided a technical guide to perform TPD surgery for the treatment of moderate diabetic foot ulcer of who had been treated in our department.
Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions.
Sci Rep
December 2024
Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518033, China.
In this study, we aimed to assess the effects of enhanced external counterpulsation (EECP) and individual shear rate therapy (ISRT) on peripheral artery function in patients with lower extremity atherosclerotic disease (LEAD). We randomly assigned 45 LEAD patients to receive 35 sessions of 45 min of EECP (n = 15), ISRT (n = 15), or sham-control (n = 15). Flow-mediated dilation in the brachial artery (brachial-FMD); 6-min walk distance; blood flow in the popliteal, posterior tibial, anterior tibial, and dorsalis pedis arteries; and plasma levels were measured before and after the 7 weeks treatment.
View Article and Find Full Text PDFRare bilateral vascular variations of the upper limb: a cadaveric case study.
J Cardiothorac Surg
December 2024
Centre for Human Anatomy Education, Department of Anatomy and Developmental Biology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.
Arterial variations in the upper limb are of significant clinical importance, especially in procedures such as venepunctures, coronary artery bypass grafts, trauma reconstructive surgeries, brachial plexus nerve blocks, and breast reconstructions. This report presents previously undocumented arterial variations in the upper limbs in a 95-year-old female cadaveric donor. We observed bilateral superficial ulnar arteries originating at the cubital fossa, deviating from the previously reported origin at the proximal brachial artery.
View Article and Find Full Text PDFMultidisciplinary approach in the management of simultaneous stroke and acute arterial ischemia of the arteries of the upper extremity: A case report.
Radiol Case Rep
February 2025
Department of Endovascular Surgery, State Budgetary Healthcare Institution "City Clinical Hospital named after M.E. Zhadkevich", Mozhaiskoe Highway, 14 121374, Moscow, Russia.
This case report presents a clinical case of management of a patient with concomitant ischemic stroke and acute arterial ischemia of the right upper limb. Emergency thrombaspiration from the middle cerebral artery improved the patient's neurological status. A hybrid intervention was carried out to restore blood flow in the right upper limb: brachial artery arteriotomy with thrombectomy through an open approach combined with endovascular recanalisation and balloon angioplasty of the forearm arteries.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!