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Between cultures and traditions: a qualitative investigation of sexual and reproductive health experiences of immigrant adolescents in Canada.
Cult Health Sex
December 2024
Department of Health Systems and Population Health, School of Public Health, University of Washington, Seattle, WA, USA.
Immigrant adolescents in Canada face challenges accessing accurate sexual and reproductive health (SRH) information and services. Many challenges stem from taboos associated with SRH, cultural and religious restrictions, and social beliefs regarding the unnecessity of SRH education for adolescents. We explored the SRH experiences of immigrant adolescents in the context of their cultural and religious perspectives.
View Article and Find Full Text PDFComprehensive identification of a disulfidptosis-associated long non-coding RNA signature to predict the prognosis and treatment options in ovarian cancer.
Front Endocrinol (Lausanne)
September 2024
Department of Gynecology III, Cangzhou Central Hospital, Cangzhou, Hebei, China.
Purpose: Distinguished from cuproptosis and ferroptosis, disulfidptosis has been described as a newly discovered form of non-programmed cell death tightly associated with glucose metabolism. However, the prognostic profile of disulfidptosis-related lncRNAs (DRLRs) in ovarian cancer (OC) and their biological mechanisms need to be further elucidated.
Materials And Methods: First, we downloaded the profiles of RNA transcriptome, clinical information for OC patients from the TCGA database.
Targeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma.
Free Radic Biol Med
November 2024
Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
Ferroptosis is a regulated cell death driven by iron-dependent lipid peroxidation and associated with drug resistance in lung adenocarcinoma (LUAD). It's found that aldehyde dehydrogenase 2 (ALDH2), which is highly mutated in East Asian populations, is correlated with response to chemotherapy in LUAD patients. The rs671 variant knock-in, downregulation, and pharmacological inhibition of ALDH2 render LUAD cells more vulnerable to ferroptosis inducers and platinum-based chemotherapy.
View Article and Find Full Text PDFSociocultural aspects of the medicalisation of infertility: a comparative reading of two illness narratives.
Med Humanit
August 2024
Department of English and Cultural Studies, Christ University, Bengaluru, Karnataka, India.
This paper is a comparative reading of variations in the medicalisation of infertility caused by sociocultural aspects, in two illness narratives by patients: Elizabeth Katkin's (2018), a story of navigating a fertility industry with polycystic ovarian syndrome and antiphospholipid syndrome in America and Rohini Rajagopal's (2021), a discussion from India of a growing awareness of medicalisation in treatment of unexplained infertility. For this purpose, it first charts scholarship on illness narratives and medicalisation, noting a historical association. Following this, it shows how infertility, a physiological symptom of reproductive incapacity or failure to show clinical pregnancy, is generally medicalised.
View Article and Find Full Text PDFIT'S OUR TIME! WHAT'S YOUR LEGACY?
Gastroenterol Nurs
August 2024
Peter Stoffan, DNP, MPA, RN, CCRN, NEA-BC, CPXP, is Magnet Program Director, Office of Nursing Excellence, NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York.
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