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Frequent changes in altitude and oxygen levels limit the practical application of traditionally derived exercise thresholds or training zones based on heart rate (HR) or blood lactate concentration (bLa). We investigated the transferability of a muscle oxygenation (SmO)-based intensity prescription between different hypoxic conditions to assess the suitability of real-time SmO measurements for ski-mountaineering (SKIMO) athletes during submaximal endurance exercise. A group of 15 well-trained male SKIMO athletes performed a graded-intensity run test in normoxia (87 m ASL, FiO = 20.

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Short-Term Intermittent Normobaric Hypoxia Combined with Light Exercise Improves Acclimatization of Cardiorespiratory Function in Inactive Adults.

Open Access J Sports Med

December 2024

Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia.

Background: Un-acclimatized individuals may experience acute altitude illness. Thus, the current study investigated the impact of short-term intermittent normobaric hypoxia (NH) combined with light exercise on the acclimatization of cardiorespiratory function to altitude in inactive adults.

Methods: This quasi-experimental study recruited 10 inactive university students (age: 26.

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The regulation of oxygen homeostasis is critical in physiology and disease pathogenesis. High Altitude environment or hypoxia (lack of oxygen) can lead to adverse health conditions such as HAPE despite initial adaptive physiological responses. Studying genetic, hematological and biochemical, and the physiological outcomes of hypoxia together could yield a comprehensive understanding and potentially uncover valuable biomarkers for predicting responses.

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In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A adenosine receptor (AAR) protect the brain from oxygen deprivation and overexertion through adjustments in cerebral blood flow, metabolism, and electric activity. Using 8-cyclopentyl-3-(3-[F]fluoropropyl)-1-propylxanthine ([F]CPFPX), a PET tracer for the AAR, we tested the hypothesis that hypoxia-induced adenosine release reduces AAR availability in the human brain.

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Article Synopsis
  • The study examined how cycling performance is affected by low oxygen levels (hypoxia) at different exercise intensities (lactate thresholds 1 and 2) while keeping heart rate constant.
  • Results showed that power output (PO) was significantly lower in hypoxic conditions at lower intensity (LT1), while differences at higher intensity (LT2) only appeared later in the exercise duration.
  • Overall, the findings suggest that exercising in simulated altitude (∼3500 m) primarily decreases cycling power at lower intensities, indicating that hypoxia impacts performance more at these levels while not significantly affecting other internal physiological responses.
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