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Sports (Basel)
December 2024
Department of Physical Education and Health in Biala Podlaska, Faculty in Biała Podlaska, Jozef Pilsudski University of Physical Education, 00-968 Warsaw, Poland.
Frequent changes in altitude and oxygen levels limit the practical application of traditionally derived exercise thresholds or training zones based on heart rate (HR) or blood lactate concentration (bLa). We investigated the transferability of a muscle oxygenation (SmO)-based intensity prescription between different hypoxic conditions to assess the suitability of real-time SmO measurements for ski-mountaineering (SKIMO) athletes during submaximal endurance exercise. A group of 15 well-trained male SKIMO athletes performed a graded-intensity run test in normoxia (87 m ASL, FiO = 20.
View Article and Find Full Text PDFOpen Access J Sports Med
December 2024
Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia.
Background: Un-acclimatized individuals may experience acute altitude illness. Thus, the current study investigated the impact of short-term intermittent normobaric hypoxia (NH) combined with light exercise on the acclimatization of cardiorespiratory function to altitude in inactive adults.
Methods: This quasi-experimental study recruited 10 inactive university students (age: 26.
Physiol Genomics
December 2024
Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics, CSIR-Institute of Genomics & Integrative Biology, Delhi, India.
The regulation of oxygen homeostasis is critical in physiology and disease pathogenesis. High Altitude environment or hypoxia (lack of oxygen) can lead to adverse health conditions such as HAPE despite initial adaptive physiological responses. Studying genetic, hematological and biochemical, and the physiological outcomes of hypoxia together could yield a comprehensive understanding and potentially uncover valuable biomarkers for predicting responses.
View Article and Find Full Text PDFJ Nucl Med
January 2025
Institute of Neuroscience and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany;
In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A adenosine receptor (AAR) protect the brain from oxygen deprivation and overexertion through adjustments in cerebral blood flow, metabolism, and electric activity. Using 8-cyclopentyl-3-(3-[F]fluoropropyl)-1-propylxanthine ([F]CPFPX), a PET tracer for the AAR, we tested the hypothesis that hypoxia-induced adenosine release reduces AAR availability in the human brain.
View Article and Find Full Text PDFEur J Sport Sci
January 2025
School of Human Sciences (Exercise and Sports Science), The University of Western Australia, Perth, Western Australia, Australia.
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