The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblastic cells in proliferative cell columns and in chorionic villi. We postulate that CRH may have an important role in early placental development and successful pregnancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.earlhumdev.2004.04.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the Anxiolytic and Antidepressant Effects of Standardized Ashwagandha () Root Extract in Wistar Rats.
Prev Nutr Food Sci
December 2024
Food Science R&D Center, Kolmar BNH, Seoul 06800, Korea.
Ashwagandha () is a popular herb in Ayurveda, the traditional medicine system in India. It is known to exert stress-mitigating properties and has been extensively studied for its safety and efficacy in various disorders. This study assessed the effects of Ashwagandha root extract (ARE) on stress in rats.
View Article and Find Full Text PDFTranslational Approach to Social Isolation During a Global Pandemic: Hippocampal Somatic Mutation and Stress.
Psychiatry Investig
December 2024
Mental Health Research Institute, National Center for Mental Health, Seoul, Republic of Korea.
Objective: The coronavirus disease-2019 (COVID-19) pandemic's social isolation has significantly impacted mental health, increasing depression and anxiety. This study explores the effects of social isolation on both humans and mice, focusing on behavioral changes and hippocampal protein expression. It also investigates genetic alterations through single-cell RNA and whole-genome sequencing (WGS).
View Article and Find Full Text PDFRapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.
Nat Commun
December 2024
Pharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for alcohol use disorder in women than men, and binge alcohol drinking is correlated with high estrogen levels, but a causal role for estrogen in driving alcohol drinking has not been established. We found that female mice displayed greater binge alcohol drinking and reduced avoidance when estrogen was high during the estrous cycle than when it was low.
View Article and Find Full Text PDFCentral corticotropin releasing hormone receptor 2 may participate in sex differential regulation of cold-evoked eating behavior.
Neuroscience
December 2024
Guangdong Provincial Key Laboratory of Animal Nutrition Control, South China Agricultural University, Guangzhou, Guangdong 510642, China; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China. Electronic address:
Corticotropin-releasing factor (CRF) is an important stress hormone, and because of the different distributions and functions of its receptors, CRF has various effects on the stress response of animals. CRF receptor 2 (CRFR2) is a functional receptor of CRF that may be related to appetite regulation and sex differences. In this study, male and female C57BL/6 mice were exposed to an ambient temperature of 4 °C, and feed intake were determined.
View Article and Find Full Text PDFEnhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone.
Nat Biomed Eng
December 2024
Department of Hematology, The First Affiliated Hospital of USTC, Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Institute of Blood and Cell Therapy and Anhui Provincial Key Laboratory of Blood Research and Applications, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
The engraftment of haematopoietic stem and progenitor cells (HSPCs), particularly in cord-blood transplants, remains challenging. Here we report the role of the corticotropin-releasing hormone (CRH) in enhancing the homing and engraftment of human-cord-blood HSPCs in bone marrow through mechanical remodelling. By using microfluidics, intravital two-photon imaging and long-term-engraftment assays, we show that treatment with CRH substantially enhances HSPC adhesion, motility and mechanical remodelling, ultimately leading to improved bone-marrow homing and engraftment in immunodeficient mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!