AI Article Synopsis
- A study observed that lymphocytes from a healthy donor changed the characteristics of allogeneic chondrosarcoma cells, shifting them from malignant to a more benign fibroblast-like appearance.
- The tumor cells exhibited structural and growth pattern changes, such as adopting a monolayered growth and losing their ability to form colonies in soft agar, along with signs of aging (senescence).
- The research suggests the need to investigate potential undiscovered lymphokines that could help reverse cancer characteristics, with an aim to clone relevant genes for genetic engineering and possible future clinical trials.
Article Abstract
A mixed population of lymphocytes from a healthy donor co-existed with an established culture of allogeneic chondrosarcoma cells, during which time the tumor cells changed from malignantly transformed to benign fibroblast-like morphology; from multilayered to a monolayered growth pattern; lost their potency to grow in colonies in soft agar; and showed signs of senescence. A discussion of possible molecular mechanisms for this event is offered. If there are as yet undiscovered lymphokines that can induce reversal of the malignant geno/phenotype, the cognate gene(s) should be cloned for genetic engineering and for the mass production of the corresponding molecular mediators for clinical trials.
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| http://dx.doi.org/10.1007/BF03033749 | DOI Listing |
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