Purpose: To examine demographic differences associated with the central corneal thickness (CCT) of donor corneas and to investigate whether these differences confirmed previous clinical studies.
Methods: CCT was prospectively measured using noncontact pachymetry among 704 eye bank corneas. The effects of gender, ethnicity, age, cause of death, times until preservation and evaluation, and endothelial cell density and morphometry on CCT were examined.
Results: The CCT of black women was significantly thinner (P = 0.05) than that of other corneal donors. The average CCT +/- SD of black women was 530 +/- 35.9 microm, whereas those of white and Hispanic women were 554 +/- 59.1 microm and 556 +/- 51.2 microm, respectively. Average values for black, white, and Hispanic men were 553 +/- 44.7 microm, 551 +/- 53.4 microm, and 543 +/- 50.4 microm, respectively. Age and cause of death did not significantly affect CCT.
Conclusion: Gender may modify racial differences of CCT. Measurements using donated corneal tissues support pachymetric differences by ethnic origin, although this finding was limited to female donors only.
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http://dx.doi.org/10.1097/01.ico.0000126327.92475.2b | DOI Listing |
BMJ Open Ophthalmol
January 2025
Department of Optometry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
Objective: This study intended to assess willingness to donate eyes and associated factors among adults in Addis Ababa City, Ethiopia.
Methods And Analysis: This study used a triangulated phenomenological mixed-methods design, involving 1293 adults and eight key informants selected through multistage and purposive sampling. Data collection involved a pretested, semistructured questionnaire for quantitative data and an open-ended guiding questionnaire for qualitative insights.
Cornea
January 2025
Tissue Engineering & Cell Therapy Group, Singapore Eye Research Institute, Singapore.
Purpose: Conjunctival autografts (CAGs) are the gold standard treatment after pterygium resection, but it is challenging to achieve consistently thin Tenon-free CAGs with manual dissection. We herein report the reproducibility and clinical outcomes of a novel algorithm to produce customizable trapezoidal CAGs using femtosecond laser (femtosecond lasers)-assisted pterygium surgery.
Methods: We first tested this algorithm in 4 pig eyes to show reproducibility.
Cell Death Dis
January 2025
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases. In this study, we elucidate the role of tsRNA-0032 in lymphangiogenesis and its molecular mechanism.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Effective storage and utilization of limited donor corneal resources are in high demand to alleviate the shortage of donor corneal tissue. Here, we designed a static air-lifted organ culture system equipped with a protective coverage membrane, namely, an air-lifted OC-P system, to provide a biomimetic physiological environment for full-thickness corneal preservation. The air-lifted OC-P system features a unique collagen-based protective coverage membrane that can offer a moist, oxygen-rich environment for corneal epithelium, produce an appropriate intraocular pressure onto the cornea by gravity, and facilitate the maintenance of the organ culture medium level for nutrient supply during corneal preservation.
View Article and Find Full Text PDFJ Clin Med
January 2025
Eye Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.
: The aim of this study was to evaluate the effect of a surgical technique for managing post-penetrating keratoplasty (PK) ectasia complicated by late endothelial failure (LEF). : A single-center pilot case series was conducted regarding consecutive patients affected by post-PK ectasia with late graft failure. Using a microkeratome, a single donor cornea was dissected to prepare a two-piece graft, comprising a larger anterior lamella made up of anterior stroma and a smaller posterior lamella made up of posterior stroma, Descemet's membrane, and endothelium.
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