This survey was carried out to examine the attitudes of nurses towards organ donation, transplantation, and procurement from the perspective of their nursing unit affiliation in a tertiary care center. Overall, 62% of nurses have already signed an organ donor card or driver's license. Those nurses willing to donate, compared with those not willing to donate, perceive renal transplants as cost effective (90% vs 38%, p less than 0.001) and successful (66% vs 47%, p less than 0.001, for estimated cadaver 1 year success rate). Nurses from some units (i.e., renal dialysis nurses), perceiving renal transplantation as being cost effective and successful, were more likely to personally report signing organ donor cards or driver's license. On the other hand, nurses from other units (i.e., the operating room) perceiving lower cost effectiveness and lower renal transplant success rates were, as a group, significantly less likely to sign organ donor cards or driver's license. Across the nursing units surveyed, both perceived transplant success and support for procurement correlated with the percent of nurses who have already signed organ donor cards/license (r = 0.94, p less than 0.02). We suspect that the nursing environment and the exposure to follow-up information on transplantation greatly influences personal attitudes towards donation. Efforts must be directed from the medical staff and within nursing to correct these shortcomings in order that all units may participate fully in the procurement-transplantation process.
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J Bioinform Syst Biol
January 2024
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, United States.
Purpose: Nitric oxide (NO) is recognized as an important biological mediator that controls several physiological functions, and evidence is now emerging that this molecule may play a significant role in the postnatal control of ocular growth and myopia development. We therefore sought to understand the role that nitric oxide plays in visually-guided ocular growth in order to gain insight into the underlying mechanisms of this process.
Methods: Choroids were incubated in organ culture in the presence of the NO donor, PAPA- NONOate (1.
Transpl Int
January 2025
Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid and removes total body immunoglobulin G (IgG) to a greater extent than other methods, enables transplantation to occur between HLA-incompatible (HLAi) donor-recipient pairs and allows patients to have greater access to KTx. However, when the project was launched there was limited data and clinical experience with desensitization in general and with imlifidase specifically.
View Article and Find Full Text PDFRev Cardiovasc Med
January 2025
Cardiac Surgery, Lausanne University Hospital CHUV Lausanne, 1011 Lausanne, Switzerland.
Background: Currently, there are no standardized guidelines for graft allocation in heart transplants (HTxs), particularly when considering organs from marginal donors and donors after cardiocirculatory arrest. This complexity highlights the need for an effective risk analysis tool for primary graft dysfunction (PGD), a severe complication in HTx. Existing score systems for predicting PGD lack superior predictive capability and are often too complex for routine clinical use.
View Article and Find Full Text PDFTransplant Direct
February 2025
Division of Transplantation, Department of Surgery, University of Iowa School of Medicine, Iowa City, IA.
Background: In 2020, liver allocation policy in the United States was changed to allow for broader organ sharing, which was hypothesized to reduce patient incentives to travel for transplant. Our objective was to describe patterns of travel for domestic liver transplant pre- and post-acuity circle (AC) implementation.
Methods: Incident adult liver transplant listings between August 16, 2016, and February 3, 2020 (pre-AC) or June 13, 2020, and December 3, 2023 (post-AC) were obtained from the Scientific Registry of Transplant Recipients.
Transplantation
January 2025
Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh PA.
Reduced dependence on antirejection agents, improved long-term allograft survival, and induction of operational tolerance remain major unmet needs in organ transplantation due to the limitations of current immunosuppressive therapies. To address this challenge, investigators are exploring the therapeutic potential of adoptively transferred host- or donor-derived regulatory immune cells. Extracellular vesicles of endosomal origin (exosomes) secreted by these cells seem to be important contributors to their immunoregulatory properties.
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