AI Article Synopsis
- The study aimed to explore how liver ischemia-reperfusion affects other organs in rats during the early stages of injury.
- Researchers divided 25 male rats into five groups based on different phases of hepatic vascular occlusion and reperfusion to measure specific biochemical markers.
- The results showed decreased antioxidant activity (SOD and ATPase) and increased injury markers (MDA, ALT, AST, BUN, AMY, CK-MB), indicating that liver ischemia-reperfusion can harm other organs shortly after the procedure.
Article Abstract
Objective: To investigate the influence of hepatic ischemia-reperfusion on other organs of rats during the early stage of injury.
Methods: Twenty-five healthy male SD rats were randomized equally into 5 groups according to the different time points in the course of hepatic vascular occlusion and reperfusion, namely pre-occlusion, the end of occlusion, and after 0.5, 2.0 and 6.0 h reperfusion, respectively. In each group the rats were killed to obtain samples at the specified time points. The contents of malondialdehyde (MDA) and superoxide dismutase (SOD) in the lung, kidney, pancreas and heart were measured in pre-occlusion and 6-hour reperfusion groups. The triphosphate (ATPase) activity in heart tissues, the contents of MDA and the activity of SOD in blood and the blood biochemistry were observed in different groups.
Results: The activity of SOD and ATPase were decreased (P<0.05) after the ischemia-reperfusion as compared with those before ischemia, but the contents of MDA, ALT, AST BUN, AMY and CK-MB increased significantly (P<0.05).
Conclusion: Liver ischemia-reperfusion can induce injury to other organs at the early stage of reperfusion.
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