AI Article Synopsis
- Amyloid deposits are found in the stroma of various neuroendocrine tumors, often linked to hormone production.
- A study of 23 adrenal pheochromocytomas revealed that 70% exhibited stromal amyloid, with many cases showing abundant deposits.
- Recognizing amyloid in pheochromocytomas is crucial for surgical pathologists, as it is not widely expected and can complicate diagnosis.
Article Abstract
Amyloid has been documented in the stroma of a number of neuroendocrine tumors. It is usually associated with elaboration of a polypeptide hormone product. Twenty-three adrenal pheochromocytomas occurring in 18 patients were graded for the extent of amyloid deposits on the hematoxylin-eosin-stained slides, confirmed to be amyloid by Congo red stain and polarization microscopy. Fourteen of 20 cases (70%) showed evidence of stromal amyloid; in two thirds of these cases, it was considered abundant. The awareness of amyloid deposits in approximately 70% of pheochromocytomas is important for surgical pathologists, as this occurrence has not been thought to be common in these tumors and might be a source of diagnostic difficulty.
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| http://dx.doi.org/10.1016/0046-8177(92)90007-p | DOI Listing |
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