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Summary: We present the case of a 50-year-old Japanese woman who was transferred to our hospital with a 2-day history of fever, sore throat, and malaise. She was diagnosed with acromegaly 9 months ago while being treated for diabetic ketoacidosis, for which she underwent pituitary surgery. She was diagnosed with hypopituitarism postoperatively and was prescribed hydrocortisone and levothyroxine.

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Objective: Copeptin is released from the posterior pituitary gland into systemic circulation in response to various stimuli, including stress. We aimed to evaluate the role of copeptin in determining the severity of the disease in patients with COVID-19.

Materials And Methods: The study was conducted prospectively in two centers between June 1, 2022, and October 1, 2022.

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Androgens Suppress Corticosteroid Binding Globulin in Male Mice, Affecting the Endocrine Stress Response.

Endocrinology

August 2024

Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands.

Biological sex affects the activity of the hypothalamus-pituitary-adrenal (HPA) axis. However, how androgen deprivation affects this axis remains largely unknown. In this study, we investigated the effect of androgen status on different components of the HPA axis in male mice.

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Introduction: Obesity, dyslipidaemia and insulin resistance are associated with hypopituitarism. The association between these conditions and Sheehan's syndrome (SS) caused by post-partum pituitary gland necrosis is poorly understood. This study aimed to assess cardiovascular risk surrogate markers in SS patients, and we compared clinical, biochemical and radiological testing with healthy controls.

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Unveiling the hidden effects of hypoxia: Pituitary damage and hormonal imbalance in fat greenling (Hexagrammos otakii).

Sci Total Environ

June 2024

Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China. Electronic address:

Article Synopsis
  • - Hypoxia stress in fisheries leads to significant fish deaths and economic losses, but the mechanisms behind its effects on fish physiology via the pituitary gland are not well understood.
  • - A study on fat greenlings exposed to varying levels of dissolved oxygen revealed that hypoxia triggers immune disorders and inflammation, along with increased reactive oxygen species (ROS) leading to oxidative stress and pituitary damage.
  • - The research shows that hypoxia stress not only harms pituitary function, reducing growth and reproductive hormones, but also impacts overall growth and gonadal development in fat greenlings.
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