Elderly patients undergoing cardiac surgery are reported to be at a higher risk for circulatory failure than younger patients, most likely because of ventricular decompensation. To assess the role of the right heart in these patients, right ventricular (RV) hemodynamics in 40 consecutive elderly patients (greater than 70 years; mean = 77.1 +/- 3.4 years) were compared with 40 consecutive younger patients (50 to 60 years; mean = 55.2 +/- 3.0 years) undergoing elective coronary artery bypass surgery. In addition to standard hemodynamic variables, RV ejection fraction (RVEF) and RV end-systolic and end-diastolic volumes (RVESV, RVEDV) were studied perioperatively using a thermodilution technique. None of the elderly patients died in the perioperative period. The course of RV function was comparable in both groups during the entire investigation period, but the absolute values of RVEF before the onset of cardiopulmonary bypass (CPB) were significantly higher in the younger patients (48.0 +/- 4.4%) than in the older patients (38.9 +/- 4.6%). RVEDV and RVESV were always higher in the older patients in the pre-bypass period than in the control group. None of the other hemodynamic parameters showed significant differences between the groups. Analysis of covariance showed no correlation between RV volume and pressure parameters. Inotropic support during and after termination of CPB was necessary more often in the older (epinephrine, 6.7 +/- 2.0 micrograms/min) than in the younger patients (epinephrine, 4.4 +/- 2.2 micrograms/min). It is concluded that older patients undergoing myocardial revascularization can have excellent results. However, they may be predisposed to right heart complications because of their reduced RV function.
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http://dx.doi.org/10.1016/1053-0770(91)90041-Q | DOI Listing |
Inflamm Bowel Dis
January 2025
Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, Box 1498, New York, NY 10029, USA.
Background: Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of somatic mutations in myeloid and lymphoid malignancy genes in the blood cells of individuals without a hematologic malignancy. Inflammation is hypothesized to be a key mediator in the progression of CHIP to hematologic malignancy and patients with CHIP have a high prevalence of inflammatory diseases. This study aimed to identify the prevalence and characteristics of CHIP in patients with inflammatory bowel disease (IBD).
View Article and Find Full Text PDFJ Laparoendosc Adv Surg Tech A
January 2025
Department of General Surgery, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Surgery for choledochal cysts (CDC) in children younger than 6 months is relatively rare. We report our experience and compare the results between Da Vinci robot-assisted hepaticojejunostomy (RAHJ) and laparoscopic-assisted hepaticojejunostomy (LAHJ) in children younger than 6 months to treat CDC. A retrospective study was conducted on all children under 6 months of age who underwent RAHJ or LAHJ at the Children's Hospital, Zhejiang University School of Medicine, from July 2018 to November 2023.
View Article and Find Full Text PDFBackground: Ruxolitinib cream has demonstrated anti-inflammatory and antipruritic activity and was well tolerated in a phase 3 study in patients aged 2-11 years with mild to moderate atopic dermatitis (AD).
Objective: This study examined the safety, tolerability, pharmacokinetics, efficacy, and quality of life (QoL) with ruxolitinib cream under maximum-use conditions and with longer-term use.
Methods: Eligible patients were aged 2-11 years with moderate to severe AD [Investigator's Global Assessment (IGA) score 3-4], and ≥ 35% affected body surface area (BSA).
J Cancer Surviv
January 2025
Department of Public and Occupational Health, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Purpose: Patients with rare cancer often experience diagnostic delays and limited treatment options, potentially negatively impacting their working lives. We explored whether those with rare vs. common cancer have an increased risk of loss of contractual employment (1) up to 2 years pre-diagnosis, (2) up to 5 years post-diagnosis, and (3) which characteristics of rare cancer survivors are associated with loss of contractual employment 5 years post-diagnosis.
View Article and Find Full Text PDFJ Natl Cancer Inst
January 2025
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Background: Adolescents and young adults (AYA) with germline CDH1 variants are at risk of overtreatment when precancer lesions are detected with endoscopic screening. We characterize diffuse-type gastric cancer prevalence and survival in AYA managed with prophylactic total gastrectomy (PTG) or endoscopic surveillance.
Methods: Prospective cohort study of 188 individuals aged 39 and younger enrolled from January 27, 2017, to May 1, 2023.
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