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The curious case of mitochondrial sirtuin in rewiring breast cancer metabolism: Mr Hyde or Dr Jekyll?
Biochim Biophys Acta Mol Basis Dis
January 2025
Department of Public Health Genomics, Centre for DNA Repair and Genome Stability (CDRGS), Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India. Electronic address:
Mammalian sirtuins are class III histone deacetylases involved in the regulation of multiple biological processes including senescence, DNA repair, apoptosis, proliferation, caloric restriction, and metabolism. Among the mammalian sirtuins, SIRT3, SIRT4, and SIRT5 are localized in the mitochondria and collectively termed the mitochondrial sirtuins. Mitochondrial sirtuins are NAD+-dependent deacetylases that play a central role in cellular metabolism and function as epigenetic regulators by performing post-translational modification of cellular proteins.
View Article and Find Full Text PDFTargeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer.
Clin Epigenetics
April 2024
Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, 315100, Zhejiang Province, China.
Background: The intriguing connection between selenium and cancer resembles a captivating puzzle that keeps researchers engaged and curious. While selenium has shown promise in reducing cancer risks through supplementation, its interaction with epigenetics in cervical cancer remains a fascinating yet largely unexplored realm. Unraveling the intricacies of selenium's role and its interaction with epigenetic factors could unlock valuable insights in the battle against this complex disease.
View Article and Find Full Text PDFThe curious case of proton migration under pressure in the malonic acid and 4,4'-bipyridine cocrystal.
IUCrJ
March 2024
MALTA-Consolider Team and Departamento de Química Física y Analítica, University of Oviedo, Julián Clavería n° 8, Oviedo 33006, Spain.
In the search for new active pharmaceutical ingredients, the precise control of the chemistry of cocrystals becomes essential. One crucial step within this chemistry is proton migration between cocrystal coformers to form a salt, usually anticipated by the empirical ΔpK rule. Due to the effective role it plays in modifying intermolecular distances and interactions, pressure adds a new dimension to the ΔpK rule.
View Article and Find Full Text PDFSmall is Beautiful: Electronic Origin and Synthetic Evolution of Single-Benzene Fluorophores.
Acc Chem Res
January 2024
Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 08826 Seoul, Korea.
ConspectusSingle-benzene fluorophores (SBFs) are small molecules that produce visible light by using only one benzene ring as the sole aromatic core. This Account centers around the chemistry of a new class of SBF that we accidentally discovered but rationally developed and refined afterward. In a failed experiment that took an unintended reaction pathway, we encountered the bright green fluorescence of -diacetylphenylenediamine ().
View Article and Find Full Text PDFThe strategic involvement of IRS in cancer progression.
Biochem Biophys Res Commun
November 2023
Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, West Bengal, India. Electronic address:
Insulin Receptor Substrate (IRS), an intracellular molecule devoid of an intrinsic kinase activity, is activated upon binding to IR which thereby works as a scaffold, organizing all signaling complexes and initiating the signaling process downstream. The level of IRS proteins and their stability in the cell is mostly maintained through the phosphorylation status of their tyrosine and serine residues. IRS is positively regulated by phosphorylation of its Tyr residues whereas a Ser residue phosphorylation attenuates it, although there exist some exceptions as well.
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