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Prenatal exposure to synthetic chemicals in relation to HPA axis activity: A systematic review of the epidemiological literature.
Sci Total Environ
December 2024
Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA. Electronic address:
Background: Pregnant people are widely exposed to numerous synthetic chemicals with known endocrine-disrupting properties (e.g., phthalates, phenols, per- and poly-fluoroalkyl substances (PFAS)).
View Article and Find Full Text PDFImpact of systemic treatments for advanced thyroid cancer on the adrenal cortex.
Eur Thyroid J
June 2024
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Background: Fatigue is a frequent adverse event during systemic treatments for advanced thyroid cancer, often leading to reduction, interruption, or discontinuation. We were the first group to demonstrate a correlation between fatigue and primary adrenal insufficiency (PAI).
Aim: The objective was to assess the entire adrenal function in patients on systemic treatments.
Determination of cortisol cut-off limits and steroid dynamics in the ACTH stimulation test: a comparative analysis using Roche Elecsys Cortisol II immunoassay and LC-MS/MS.
Endocrine
July 2024
Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Purpose: Measurement of cortisol concentrations is method dependent. The study aimed to establish assay-specific cut-off limits for cortisol after adrenocorticotropic hormone (ACTH) stimulation, comparing Roche Elecsys Cortisol II immunoassay to liquid chromatography-mass spectrometry (LC-MS/MS), and to assess the impact of patient characteristics, estrogen containing oral contraceptives as well as relation to other adrenocortical steroid hormone dynamics.
Methods: One hundred healthy participants underwent a 250 μg ACTH-test, with plasma samples analyzed using ElecsysCortI, ElecsysCortII, and LC-MS/MS.
A New Approach - Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency.
NEJM Evid
February 2023
Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee.
Adrenal insufficiency is a common and potentially life-threatening endocrine disorder that can be drug induced or endogenous and of adrenal (primary) or pituitary/hypothalamic (secondary/tertiary) origin. Of particular concern in drug-induced disease is the patient with glucocorticoid- or opioid-induced adrenal insufficiency. Adrenal insufficiency of any cause is typically diagnosed biochemically with a subnormal morning serum cortisol (the circadian, awakening peak) and serum dehydroepiandrosterone sulfate, followed by or simultaneously with an assessment of the acute (30 and 60 minutes) serum cortisol response to injected synthetic corticotropin (ACTH), if clinically indicated.
View Article and Find Full Text PDFSalivary Cortisol and Cortisone Measurement Improves ACTH Stimulation Testing in Women Taking Oral Contraceptives.
J Clin Endocrinol Metab
July 2024
Division of Endocrinology and Molecular Medicine, Departments of Medicine, Surgery and Physiology, and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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