Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Petroclival meningioma regression after combined oestrogen and nomegestrol acetate interruption.
BMJ Case Rep
January 2025
Neurosurgery, CHU de Liege Hospital Sart Tilman, Liege, Belgium
Meningioma regression after progestin treatment interruption is already established. Zoely is a combined oral contraceptive including oestradiol and progestin (nomegestrol acetate). The effect of combined oestrogen with nomegestrol acetate on meningioma is currently unknown.
View Article and Find Full Text PDFDisparities in menstrual bleeding management during acute venous thromboembolism treatment: A review of UK practice and a call for clinical studies.
Thromb Res
January 2025
Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, B15 2TT, United Kingdom of Great Britain and Northern Ireland; Department of Haematology, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom of Great Britain and Northern Ireland.
Background: Heavy menstrual bleeding (HMB) is a significant clinical burden for premenopausal individuals treated with anticoagulation for acute venous thromboembolism (VTE). Despite its prevalence, HMB management remains poorly studied, with wide variation in clinical practice.
Objectives: The current study aimed to explore current UK practices in managing HMB in anticoagulated individuals and identify areas requiring clinical research to address disparities.
The Effects of Anlotinib Combined with Chemotherapy following Progression on Cyclin-Dependent Kinase 4/6 Inhibitor in Hormone Receptor-Positive Metastatic Breast Cancer.
Breast J
January 2025
Department of Chemotherapy Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Purpose: Endocrine therapy combined with cyclin-dependent kinase (CDK) 4/6 inhibitors (CDK4/6i) is the preferred treatment for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC). However, there are currently no recommendations for therapeutic strategies after progression on CDK4/6i-based treatment. This study aimed to examine the efficacy and safety of anlotinib plus chemotherapy in HR+/HER2- MBC after progression on CDK4/6 inhibitors.
View Article and Find Full Text PDFMesonephric tubules expressing estrogen and androgen receptors remain in the rete ovarii of adult mice.
Cell Tissue Res
January 2025
Department of Anatomy, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
The rete ovarii and epoophoron in females are homologous structures of the rete testis and efferent/epididymal duct in males and are derived from the developing rete cells and mesonephric tubules, respectively. Sex steroid hormones play a critical role in reproductive function for both sexes, and we recently reported expression patterns of sex steroid receptors in developing male reproductive tracts. However, their expression patterns in females remain unclear.
View Article and Find Full Text PDFEvidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts.
Cell Commun Signal
November 2024
Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.
Article Synopsis
- Endocrine therapy improves outcomes for ERα+ breast cancer, but resistance remains a key challenge, often linked to mutations like Y537S in the hormone-binding domain of ERα.
- Researchers conducted coculture experiments to study interactions between mutant breast cancer cells (MCF-7YS) and fibroblasts (both normal and cancer-associated) to see how these interactions influence cancer progression.
- The study found that the Y537S mutation led to changes in fibroblast behavior and protein expression, with increased YAP1 involvement, suggesting that mutant breast cancer cells can enhance their growth and invasion capabilities through interactions with the tumor microenvironment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!