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Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.
Sci Rep
January 2025
Department of Hematology and Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children's Hospital of Chongqing Medical University, No 136 Zhongshan 2 road, YuZhong district, Chongqing, 400014, China.
Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report a novel fusion gene and investigate its pathogenic role in acute lymphoblastic leukemia (ALL). We engineer a transposon transfection system expressing the TOP2B::AFF2 transcript and introduce it into Ba/F3 cells.
View Article and Find Full Text PDFAssociation between prenatal depressive symptoms and receipt of recommended maternal and infant care postpartum.
J Affect Disord
January 2025
Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT 06510, USA; Center for Methods in Implementation and Prevention Sciences, Yale University, New Haven, CT 06510, USA. Electronic address:
Background: Maternal mental health can impact health care access and utilization for both the birthing parent and infant. We examined the association between prenatal depressive symptoms (episodic and chronic) and receipt of the postpartum 6-week visit and infant vaccinations in the first year postpartum.
Methods: Postpartum individuals (N = 672) who attended Expect With Me group prenatal care in Nashville, Tennessee and Detroit, Michigan completed surveys during the second and third trimesters of pregnancy, as well as 6- and 12- months postpartum.
Grandparental childcare and subjective well-being: The role of activities and reasons for care.
Soc Sci Med
January 2025
Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, 355a, London, WC1E 7HB, UK.
Despite extensive research on the impact of grandchild care on grandparents' well-being, no studies have examined the frequency of activities that grandparents engage in with their grandchildren or the reasons for care using nationally representative data. We address this gap using waves 8 (2016/2017) and 9 (2018/19) of the English Longitudinal Study of Ageing, a nationally representative study of English older adults. We employ hybrid regression models to distinguish between within- and between-individual effects on grandparents' subjective wellbeing, as captured by quality of life and depressive symptoms.
View Article and Find Full Text PDFIntergenerational transmission of childhood interpersonal trauma in adults entering therapy for intimate partner violence: The role of identity diffusion.
Child Abuse Negl
January 2025
Département de psychologie, Université de Sherbrooke, Canada. Electronic address:
Background: Childhood Interpersonal Trauma (CIT) is a major public health issue that increases the risk of perpetrating and sustaining intimate partner violence (IPV) in adulthood, perpetuating intergenerational cycles of violence. Yet, the explanatory mechanisms behind the intergenerational transmission of trauma warrant further exploration.
Objective: This study explored identity diffusion as an explanatory mechanism linking cumulative and individual CIT (sexual, physical and psychological abuse, physical and psychological neglect, witnessing parental physical or psychological IPV, bullying) to IPV (sexual, physical, psychological, coercive control) and to the next generation's exposure to family violence.
Parenthood, gender, and turning points to crime for young people in Latin America.
Adv Life Course Res
January 2025
Department of Political Science and Public Law, Autonomous University of Barcelona, Cerdanyola del Vallès, Bellaterra 08193, Spain.
In very different societal contexts, parenthood has been identified as a critical turning point in life course trajectories. In this qualitative study, we explore parenthood as a turning point for 40 young women and 40 young men in prisons across Latin America. We study the impact of parenthood on criminal trajectories, identify gender differences, and analyze the different mechanisms at work.
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