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Could the transcription factor AtnN coordinating the aspercryptin secondary metabolite gene cluster in Aspergillus nidulans be a global regulator?
Fungal Biol
December 2024
Department of Molecular Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Hungary; HUN-REN-DE Fungal Stress Biology Research Group, Debrecen, Hungary. Electronic address:
Products of dormant secondary metabolite gene clusters of fungal genomes can be exploited for medical purposes as bioactive agents. These clusters can be switched on under oxidative stress and may endow fungi with a versatile chemical armory in a competitive niche. In Aspergillus nidulans, the aspercryptin gene cluster, including the synthase [atnA (AN7884)] and its transcription factor (atnN), was activated under menadione sodium bisulfite (MSB) treatment.
View Article and Find Full Text PDFMis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD.
Nature
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Article Synopsis
- - Alternative splicing includes microexons in neuronal proteins, which are often linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
- - A specific 24-nucleotide microexon in the RNA-binding protein CPEB4, previously shown to be less included in individuals with ASD, plays a critical role in regulating gene expression linked to neurodevelopment.
- - The study finds that this microexon helps maintain the flexible regulation of CPEB4 during neuronal activation by preventing its aggregation, allowing it to switch from repressing to activating translation of genes.
Optimizing Nitrate and Tryptone to Enhance Growth and Triacylglycerol Accumulation in .
J Microbiol Biotechnol
December 2024
Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
, a unicellular diatom, is considered a potential feedstock for the production of biofuel and a promising producer for high-value products eicosapentaenoic acid and fucoxanthin. However, a high-efficient cultivating strategy to achieve commercial production of triacylglycerol (TAG) from the diatom is an urgent demand. In this study, we optimized the content and ratio of nitrate and tryptone in the medium to enhance biomass and TAG accumulation simultaneously.
View Article and Find Full Text PDFThermal Inactivation of Cells of Salmonella spp. in Pot Pies Prepared With a Beef, Chicken, or Meat Alternative Filling, With and Without Gravy, During Cooking in a Convection Oven.
J Food Prot
December 2024
U.S. Department of Agriculture, Agricultural Research Service, Wyndmoor, PA 19038, USA.
Cooking parameters elaborated in the U.S. Department of Agriculture's Food Safety and Inspection Service Cooking Guideline for Meat and Poultry Products (Appendix A) were evaluated for inactivation of Salmonella spp.
View Article and Find Full Text PDFInsights on aggregation-algae consortium based removal of sulfamethoxazole: Unraveling removal effect, enhanced method and toxicological evaluation.
J Environ Manage
November 2024
Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China. Electronic address:
The escalating occurrence of the antibiotic Sulfamethoxazole (SMX) in the environment presents a significant global threat to ecological systems and human health. Despite the growing interest in using microalgae for antibiotic biodegradation, strategies to enhance SMX elimination remain underexplored. In this study, we isolated a novel aggregation-algae consortium (AAC) from a municipal wastewater treatment plant (WWTP) and examined its potential for SMX removal, optimized culture conditions, SMX metabolite fate and the physicochemical impact on microalgal cells.
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