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[Effect of electroacupuncture on denervated skeletal muscle atrophy in rats based on p38 MAPK signaling pathway].
Zhongguo Zhen Jiu
January 2025
College of TCM, Chongqing Medical University, Chongqing Key Laboratory of TCM for Prevention and Treatment of Metabolic Diseases, Chongqing 410007, China.
Objective: To assess the impacts of electroacupuncture (EA) on the gait, oxidative stress, inflammatory reaction, and protein degradation in the rats of denervated skeletal muscle atrophy, and explore the potential mechanism of EA for alleviating denervated skeletal muscle atrophy.
Methods: Forty male SD rats, 8 weeks old, were randomly assigned to a sham-surgery group, a model group, an EA group, and a p38 MAPK inhibitor group, with 10 rats in each group. The right sciatic nerve was transected to establish a rat model of denervated skeletal muscle atrophy in the model group, the EA group and the p38 MAPK inhibitor group.
DLK-dependent axonal mitochondrial fission drives degeneration after axotomy.
Nat Commun
December 2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Currently there are no effective treatments for an array of neurodegenerative disorders to a large part because cell-based models fail to recapitulate disease. Here we develop a reproducible human iPSC-based model where laser axotomy causes retrograde axon degeneration leading to neuronal cell death. Time-lapse confocal imaging revealed that damage triggers an apoptotic wave of mitochondrial fission proceeding from the site of injury to the soma.
View Article and Find Full Text PDFCircadian misalignment has been associated with obesity both in rodents and humans. Brown adipose tissue (BAT) thermogenesis contributes to energy expenditure and can be activated in adults to reduce body weight. Although previous studies suggest control of BAT thermogenesis by the circadian clock, the site and mechanisms of regulation remain unclear.
View Article and Find Full Text PDFComplement C5a Implication in Axonal Growth After Injury.
Cells
October 2024
Aix-Marseille University, CNRS, ISM, 13009 Marseille, France.
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to restore the lost functions. This work aimed at investigating the Complement C5a effect on axonal growth after axotomy in vitro.
View Article and Find Full Text PDFEIF4A3-Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1-867aa.
Adv Sci (Weinh)
December 2024
Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Sciences, Shanghai University, Nantong, 226011, China.
Article Synopsis
- Researchers have identified a specific circular RNA, circDdb1, that plays a significant role in causing skeletal muscle atrophy, which is often linked to aging and various diseases.
- CircDdb1 levels are significantly increased during muscle atrophy, and adding it artificially leads to more atrophy, whereas its inhibition can prevent muscle loss caused by different factors.
- The study also finds that circDdb1 regulates protein translation via its interaction with eukaryotic elongation factor 2 (eEF2) and suggests that targeting circDdb1 could serve as a new therapeutic approach to combat muscle atrophy.
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