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Real-time trajectory imaging of alpha particles emitted from actinium-225 and its daughter radionuclides.
Sci Rep
January 2025
Faculty of Science and Engineering, Waseda University, Tokyo, Japan.
In targeted alpha-particle therapy, actinium-225 (Ac-225) has emerged as a radionuclide of potential, driving extensive efforts to develop innovative radiopharmaceuticals. High-resolution imaging of alpha particles is required for precisely detecting alpha-emitting radionuclides in cellular environments and small organs. Here, we report real-time trajectory imaging of alpha particles emitted by Ac-225 and its daughter radionuclides, utilizing an alpha particle trajectory imaging system.
View Article and Find Full Text PDFReal-time dose measurement in minibeam radiotherapy using radioluminescence imaging.
Phys Med
January 2025
IRCCS San Raffaele Scientific Institute, Experimental Imaging Center, Milan, Italy. Electronic address:
Purpose: Minibeam radiotherapy (MBRT) uses small parallel beams of radiation to create a highly modulated dose pattern. The aim of this study is to develop an optical radioluminescence imaging (RLI) approach to perform real-time dose measurement for MBRT.
Methods: MBRT was delivered using an image-guided small animal irradiator equipped with a custom collimator.
Design optimization of a 1-D array of stemless plastic scintillation detectors.
Med Phys
January 2025
Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Background: A stemless plastic scintillation detector (SPSD) is composed of an organic plastic scintillator coupled to an organic photodiode. Previous research has shown that SPSDs are ideally suited to challenging dosimetry measurements such as output factors and profiles in small fields. Lacking from the current literature is a systematic effort to optimize the performance of the photodiode component of the detector.
View Article and Find Full Text PDFSuperimposed Wavefront Imaging of Diffraction-enhanced X-rays: sparsity-aware CT reconstruction from limited-view projections.
Int J Comput Assist Radiol Surg
December 2024
High Energy Accelerator Research Organization, Tsukuba, Ibaraki, 305-0801, Japan.
Purpose: In this paper, we describe an algebraic reconstruction algorithm with a total variation regularization (ART + TV) based on the Superimposed Wavefront Imaging of Diffraction-enhanced X-rays (SWIDeX) method to effectively reduce the number of projections required for differential phase-contrast CT reconstruction.
Methods: SWIDeX is a technique that uses a Laue-case Si analyzer with closely spaced scintillator to generate second derivative phase-contrast images with high contrast of a subject. When the projections obtained by this technique are reconstructed, a Laplacian phase-contrast tomographic image with higher sparsity than the original physical distribution of the subject can be obtained.
Characterization of intrinsic radiation in LYSO scintillators using GEANT4 and SimSiPM simulations.
Appl Radiat Isot
March 2025
Istinye University, Istanbul, 34010, TR, Turkey. Electronic address:
The intrinsic radiation spectra of LYSO scintillators are investigated through detailed GEANT4 and SimSiPM simulations, focusing on how changes in configuration and size influence the radiation characteristics. Using these simulation packages together, a comprehensive simulation of the physical processes as well as a detailed simulation of the photodetector response, including factors such as dark count rate, optical crosstalk, afterpulse, noise, and saturation effects, was performed. The results of the simulations indicate that the primary factor affecting the intrinsic radiation pattern is the total volume of the crystal, rather than surface treatments or minor geometric variations.
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