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Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy.
Drug Deliv
November 2018
a Department of Pharmaceutics and Biopharmaceutics , University of Marburg, Marburg , Germany.
Photodynamic therapy (PDT) that involves ergonomically delivered light in the presence of archetypical photosensitizer such as Protoporphyrin IX (PpIX) is a time-honored missile strategy in cancer therapeutics. Yet, the premature release of PpIX is one of the most abundant dilemma encounters the therapeutic outcomes of PDT due to associated toxicity and redistribution to serum proteins. In this study, ultrastable tetraether lipids (TELs) based liposomes were developed.
View Article and Find Full Text PDF[Conjugates of porphyrins with carbohydrates].
Bioorg Khim
October 2003
Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571 Russia.
The methods of synthesis and properties of prophyrins covalently linked with carbohydrates are considered. Special attention is paid to the prospects of using this class of compounds as photosensitizers in photodynamic cancer therapy.
View Article and Find Full Text PDFEffect of high fiber vegetable-fruit diet on the activity of liver damage and serum iron level in porphyria cutanea tarda (PCT).
Med Sci Monit
May 2001
Baltic Humanistic University, Faculty of Pedagogics, ul. Monte Cassino 6, 75-412 Koszalin, Poland.
Background: During the treatment of coronary heart disease with a vegetable-fruit diet, we have observed the positive effect of the treatment on PCT patients. Therefore, we have now examined the short-term results of the diet on the selected PCT activity parameters. The study was approved by our Review Board.
View Article and Find Full Text PDFMeasurement of the rate of uptake and subcellular localization of porphyrins in cells using fluorescence digital imaging microscopy.
Photochem Photobiol
April 1994
Department of Chemistry and Biological Chemistry, University of Essex, Colchester, England.
A fluorescence imaging system incorporating a cooled slow-scan charge-coupled device camera was used to study the rate of uptake and subcellular localization of prophyrins in living cells. Measurements were carried out on human dermal fibroblasts (D532) using two different prophyrins meso-tetra(4-N-methylpyridyl)porphine (TMPP) and meso-tetra(4-N-hexylpyridyl)porphine (THPP). It was observed that TMPP was rapidly taken up by cells and principally located in the nucleus.
View Article and Find Full Text PDF3-[2-(2,4,6-Trimethylphenyl)thioethyl]-4-methylsydnone was shown to be a potent porphyrinogenic agent in chick embryo liver cells. The accumulation of protoporphyrin IX was consistent with the finding that ferrochelatase activity was inhibited. 3-Benzyl-4-phenylsydnone did not inhibit ferrochelatase activity and protoporphyrin IX was found to constitute only a minor fraction of the prophyrins.
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