From the chemical evidence presented it appears that the toxicity associated with the somatic antigen of Type Z Sh. paradysenteriae may be attributed to an entity distinct from the known components of the complex. That this substance is neither the protein, the lipid, nor the carbohydrate component of the antigen is evident. Because of its lability to chemical manipulation, the nature of the toxic component, has not yet been ascertained.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136025PMC
http://dx.doi.org/10.1084/jem.92.1.25DOI Listing

Publication Analysis

Top Keywords

nature toxic
8
toxic component
8
somatic antigen
8
component somatic
4
antigen shigella
4
shigella paradysenteriae
4
paradysenteriae type
4
type flexner
4
flexner chemical
4
chemical evidence
4

Similar Publications

Neuropathic pain (NP) imposes a significant burden on individuals, manifesting as nociceptive anaphylaxis, hypersensitivity, and spontaneous pain. Previous studies have shown that traumatic stress in the nervous system can lead to excessive production of hydrogen sulfide (HS) in the gut. As a toxic gas, it can damage the nervous system through the gut-brain axis.

View Article and Find Full Text PDF

Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer care. A significant innovation in this area is the use of nanotechnology, specifically nanoparticles, to tackle various challenges in cancer treatment.

View Article and Find Full Text PDF

Strategies to increase the robustness of microbial cell factories.

Adv Biotechnol (Singap)

March 2024

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China.

Engineering microbial cell factories have achieved much progress in producing fuels, natural products and bulk chemicals. However, in industrial fermentation, microbial cells often face various predictable and stochastic disturbances resulting from intermediate metabolites or end product toxicity, metabolic burden and harsh environment. These perturbances can potentially decrease productivity and titer.

View Article and Find Full Text PDF

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and remains a fatal malignancy in most patients. Only 20% to 30% of patients can be treated with potentially curative surgical resection. Local therapies such as radioembolization and hepatic arterial perfusion may be a more effective treatment strategy.

View Article and Find Full Text PDF

Anti-Inflammatory Activities of Some Plants of Genus : Insights from In Vitro, In Vivo, and Human Studies.

J Exp Pharmacol

January 2025

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.

This narrative review intends to provide thorough information on the anti-inflammatory activities of plants, the largest genus of the family Zingiberaceae. The articles were searched on the PubMed database using 'Alpinia AND anti-inflammatory activity' as the keywords, filtered to articles published from 2020 to 2024 and free full-text. Of the approximately 248 members of the genus plants, the most commonly studied for their anti-inflammatory activities are , , , and .

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!