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Is there a difference in the results of the video head impulse test in patients with a nosological diagnosis of Ménière's Disease and Vestibular Migraine?
Codas
January 2025
Programa Associado de Pós-graduação em Fonoaudiologia (Mestrado) - PPgFon, Universidade Federal do Rio Grande do Norte - UFRN - Natal (RN), Brasil.
Purpose: To compare vestibulo-ocular reflex (VOR) gain values, gain symmetry between the semicircular canals (SCCs), and saccadic parameters in patients with a nosological diagnosis of Ménière's disease (MD) and vestibular migraine (VM).
Methods: Observational, descriptive, cross-sectional, retrospective study, approved by the Research Ethics Committee, under evaluation report number 4.462.
Background: Cardiovascular diseases are the leaders in morbidity and mortality worldwide. The most common cause of emergency hospitalization of cardiac patients is acute coronary syndrome, represented by acute forms of coronary heart disease: unstable angina and myocardial infarction. Among the young population (18-44 years old, according to WHO), in contrast to the older cohort, there has been a significant increase in cardiovascular morbidity over the last two decades.
View Article and Find Full Text PDFELECTROPHYSIOLOGICAL CHANGES IN THE PARTICIPANTS OF THE LIQUIDATION OF THE CONSEQUENCES OF THE CHORNOBYL ACCIDENT AND THE MILITARY PERSONNEL OF THE UKRAINIAN DEFENSE FORCES RECOVERING FROM CORONAVIRUS DISEASE (COVID-19).
Probl Radiac Med Radiobiol
December 2024
State Institution «National Research Center of Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Objective: to conduct a clinical and neurophysiological study of Chornobyl clean-up workers and military personnelof the Armed Forces of Ukraine (AFU) with previous coronavirus disease (COVID-19) and individuals of the comparison groups to study the impact of long-term effects of ionizing radiation, psychoemotional stress and previouscoronavirus infection on cerebral functioning.
Materials And Methods: A prospective clinical study of Chornobyl clean-up workers and servicemen of the ArmedForces of Ukraine (AFU) who had coronavirus disease (COVID-19) and individuals of the comparison groups. Themain group - 30 males participated in liquidating the consequences of the Chornobyl Nuclear Power Plant (ChNPP)accident with previously verified COVID-19 (Chornobyl clean-up workers).
Could Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?
Diagnostics (Basel)
November 2024
Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
View Article and Find Full Text PDFSwitch/Sucrose Nonfermentable-Deficient Tumors-Morphology, Immunophenotype, Genetics, Epigenetics, Nosology, and Therapy.
Lab Invest
January 2025
Department of Pathology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
About 20% of human cancers harbor mutations of genes encoding switch/sucrose nonfermentable (SWI/SNF) complex subunits. Deficiency of subunits of the complex is present in 10% of non-small-cell lung cancers (NSCLC; SMARCA4/SMARCA2 deficient), 100% thoracic SMARCA4/A2-deficient undifferentiated tumors (TSADUDT; SMARCA4/A2 deficient), malignant rhabdoid tumor, and atypical/teratoid tumor (SMARCB1-deficient), >90% of small cell carcinoma of the ovary, hypercalcemic type (SMARCA4/SMARCA2 deficient), frequently in undifferentiated/dedifferentiated endometrial carcinoma (SMARCA4, SMARCA2, SMARCB1, and ARID1A/B deficient), 100% SMARCA4 deficient undifferentiated uterine sarcoma (SMARCA4 deficient); and in various other tumors from multifarious anatomical sites. Silencing of SWI/SNF gene expression may be genomically or epigenetically driven, causing loss of tumor suppression function or facilitating other oncogenic events.
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