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| http://dx.doi.org/10.1136/ard.9.2.97 | DOI Listing |
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Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability.
Eur Heart J
November 2022
Department of Pharmacology, College of Pharmacy, Second Military Medical University/Naval Medical University, Shanghai, China.
Aims: Exercise confers protection against cardiovascular ageing, but the mechanisms remain largely unknown. This study sought to investigate the role of fibronectin type-III domain-containing protein 5 (FNDC5)/irisin, an exercise-associated hormone, in vascular ageing. Moreover, the existence of FNDC5/irisin in circulating extracellular vesicles (EVs) and their biological functions was explored.
View Article and Find Full Text PDFWeight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD.
JHEP Rep
June 2021
Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Background & Aims: A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exercise on individual tissues (liver, adipose tissue, and skeletal muscle) were retrospectively studied.
Methods: Data from Japanese obese men with NAFLD in a 3-month exercise regimen were analysed and compared with those in a 3-month dietary restriction program designed to achieve weight loss.
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