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Evaluation of severe rhabdomyolysis on day 30 mortality in trauma patients admitted to intensive care: a propensity score analysis of the Traumabase registry.
Crit Care
November 2024
Department of Anesthesiology and Intensive Care Medicine, Percy Military Training Hospital, 2 rue du Lieutenant Raoul Batany, 92140, Clamart, France.
Article Synopsis
- - The study aimed to determine if severe traumatic rhabdomyolysis (with CK levels > 5000 U/L) affects the likelihood of death within 30 days for trauma patients, utilizing a causal inference approach in a multicenter cohort in France.
- - An analysis of 8592 patients revealed that 18% had severe RM, primarily affecting young males with blunt trauma, yet it did not significantly impact overall 30-day mortality rates despite associated complications.
- - While patients with severe RM had higher rates of multiorgan failure and septic shock during ICU stays, this risk was not a significant predictor of death when adjusted for confounding factors.
Salvage Reirradiation with Proton Beam Therapy for Locoregionally Recurrent Non-Small Cell Lung Cancer.
Cancers (Basel)
October 2024
Department of Radiation Oncology, City of Hope Orange County, Lennar Foundation Cancer Center, Irvine, CA 92618, USA.
Background/objectives: This retrospective study evaluates outcomes of 66 patients who underwent reirradiation (re-RT) with proton beam therapy (PBT) for recurrent non-small cell lung cancer.
Methods: Toxicity was scored via the CTCAE v5.0, and outcomes estimated using the Kaplan-Meier method, with associations evaluated via Cox proportional hazards and logistic regression analyses.
MECP2 Variants in Males: More Common than Previously Appreciated.
Pediatr Neurol
December 2024
Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:
Article Synopsis
- The study aims to analyze the ages and genetic MECP2 variants of recently identified males, laying the groundwork for further investigation into their clinical characteristics.
- Genetic data were collected from a parent group, focusing on whether MECP2 variants were newly developed or inherited, as well as the prevalence of mosaicism among those meeting Rett syndrome criteria.
- Out of 59 males examined, the majority had de novo variants, and findings emphasize the necessity for improved diagnostic processes and equitable access to therapeutic options for those with MECP2 variants.
Could hosting medical students doing audits help to combat burnout in primary care?
Br J Gen Pract
August 2024
GP, Dr Curran and Partners, Manor Health Centre, London.
Optimal management of radiation pneumonitis: Findings of an international Delphi consensus study.
Lung Cancer
June 2024
Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; University of Toronto Department of Radiation Oncology, Toronto, ON, Canada. Electronic address:
Purpose: Radiation pneumonitis (RP) is a dose-limiting toxicity for patients undergoing radiotherapy (RT) for lung cancer, however, the optimal practice for diagnosis, management, and follow-up for RP remains unclear. We thus sought to establish expert consensus recommendations through a Delphi Consensus study.
Methods: In Round 1, open questions were distributed to 31 expert clinicians treating thoracic malignancies.
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