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Formulation Factors Affecting the Formation of Visible-Bubbles During the Reconstitution Process of Freeze-Dried Etanercept Formulations: Protein Concentration, Stabilizers, and Surfactants.
AAPS J
January 2025
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated during the reconstitution process for many freeze-dried protein formulations, which can potentially affect the management efficiency of staff, patient compliance, and product quality.
View Article and Find Full Text PDFCharacterization of free and bound polymethoxyflavones in the dried peel of Citrus reticulata "Chachi" through fingerprint RDA ions and reversed-phase column retention by UPLC-Q-TOF-MS/MS.
Food Chem
January 2025
Engineering Research Center of Health Food Design & Nutrition Regulation, Dongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China. Electronic address:
Polymethoxyflavones (PMFs) from citrus peel, including permethoxylated PMFs and hydroxylated PMFs (OH-PMFs), have attracted much attention due to their potential strong biological activities. However, characterization of PMFs through LC-MS analysis was challenged due to numerous substituent positions in flavone. In this study, twelve PMF standards were analyzed by UPLC-QTOF-MS/MS to present fingerprint retro-Diels-Alder (RDA) ions ([B], A and B(C) associated ions).
View Article and Find Full Text PDFBiosynthesis of Zinc Oxide Nanoparticles Using Dried Leaves of Camellia sinensis: Methods to Characterize and Assess Their Effects on Mesenchymal Stem Cell Viability.
Methods Mol Biol
January 2025
Department of Food Quality Control and Analysis, Vocational School of Health Services, Istanbul Gelisim University, Avcılar, Istanbul, Turkey.
Stem cell nanotechnology (SCN) is an important scientific field to guide stem cell-based research of nanoparticles. Currently, nanoparticles (NPs) have a rich spectrum regarding the sources from which they are obtained (metallic, polymeric, etc.), the methods of obtaining them (physical, chemical, biological), and their shape, size, electrical charge, etc.
View Article and Find Full Text PDFPro-inflammatory effects of inhaled Great Salt Lake dust particles.
Part Fibre Toxicol
January 2025
Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Background: Climate change and human activities have caused the drying of marine environments around the world. An example is the Great Salt Lake in Utah, USA which is at a near record low water level. Adverse health effects have been associated with exposure to windblown dust originating from dried lakebed sediments, but mechanistic studies evaluating the health effects of these dusts are limited.
View Article and Find Full Text PDFThe potential function of chalcone isomerase (CHI) gene on flavonoid accumulation in Amomum tsao-ko fruit by transcriptome and metabolome.
Int J Biol Macromol
January 2025
Key Laboratory for Research and Utilization of Characteristic Biological Resources in Southern Yunnan, College of Biological and Agricultural Sciences, Honghe University, Mengzi 661199, Yunnan, China. Electronic address:
Flavonoids are the major medicinally active ingredients that exert potential effects in Amomum tsao-ko. In total, 277 flavonoid metabolites were identified in fresh and dried fruits of three different accessions of A. tsao-ko (Amomum tsao-ko), which could be classified into eight classes with more metabolites classified as flavonol.
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