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[Neuromuscular monitoring: methods and machines].
Anasthesiol Intensivmed Notfallmed Schmerzther
May 2008
Zentrum für Anästhesiologie, Intensiv-, Notfallmedizin und Schmerztherapie, Klinikum Ludwigsburg.
Muscle relaxing agents are clinically in use for general anaesthesia to optimize the conditions to the endotracheal intubation as well as the surgical conditions. Therefore different musclerelaxants with specific pharmacological characteristics are available. Many factors that depend on the condition of the patient and the used musclerelaxant agent influence the duration of the neuromuscular blockade.
View Article and Find Full Text PDFThe effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39.
Acta Anaesthesiol Scand
September 2007
Future therapeutic strategies in autoimmune myasthenia gravis.
Ann N Y Acad Sci
September 2003
Department of Biochemistry, Hellenic Pasteur Institute, 11521 Athens, Greece.
Antibodies against muscle acetylcholine receptor (AChR) undoubtedly play a critical role in the pathology of most myasthenia gravis (MG) cases. Selective elimination of the majority of these antibodies should result in a considerable improvement of the MG symptoms. Such a specific elimination could be achieved by AChR-based immunoadsorbents.
View Article and Find Full Text PDFSynthesis and structure-activity relationships of neuromuscular blocking agents.
Curr Med Chem
August 2002
Steroid Research Section, Chemical Works of Gedeon Richter Ltd.,10, POB 27, Budapest, H-1475, Hungary.
The first use of neuromuscular blocking agents (muscle relaxants) in clinical practice (1942) revolutionised the practice of anaesthesia and started the modern era of surgery. Since 1942 introduction of tubocurarine (18) neuromuscular blocking agents have been used routinely to provide skeletal muscle relaxation during surgical procedures allowing access to body cavities without hindrance from voluntary or reflex muscle movement. After the introduction of tubocurarine and the depolarizing suxamethonium chloride (4) (1949) several nondepolarizing steroidal and nonsteroidal neuromuscular blocking agents with different onset time and duration of effect were introduced e.
View Article and Find Full Text PDFThe nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.
J Comp Physiol B
April 2002
Department of Biological Sciences, Institute of Environmental and Natural Sciences, Lancaster University, Lancaster LA1 4YQ, UK.
The characteristics of the acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) receptors of Deroceras buccal muscle were examined using specific pharmacological probes and sucrose gap electrophysiological analysis. ACh induced concentration-dependent smooth tonic contractures coupled with considerable depolarisation from the normal resting membrane potential of -30.6 mV.
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