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The authors, using rabbits for their experiments (26), studied the effect of application of thyroid hormones (Thyreoiodine Spofa) and that exclusion of these hormones by means of thyroidectomy on the mass of the heart, the concentration of nucleic acids and proteins in the subcellular structures of the heart muscle of intact animals. They observed that administration of hormones of the thyroid gland in a relatively short time led to hyperthrophy of the heart, increased concentration of ribonucleic acid and to modifications of the concentration of proteins in the subcellular structures of the heart muscle. Exclusion of the thyroid hormones, on the other hand, caused a decrease of the mass of the myocardium, decrease concentrations of RNA, DNA and also that of the proteins of the mitochondrial and myofibrillar fractions of the myocardium.
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