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Preservation solution protects isolated hair micrografts by inhibiting apoptosis of hair bulb.
Life Sci
January 2025
Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province 510515, China. Electronic address:
Aims: To investigate the effectiveness of histidine-tryptophan-ketoglutarate (HTK) solution compared to Ringer's (RS) solution for preserving isolated hair follicles (HFs), focusing on structural integrity, cell viability, apoptosis prevention, and identifying the mechanisms of cell death during the preservation period.
Materials And Methods: Isolated human HFs were preserved in HTK or RS solution for periods ranging from 2 to 12 h. Morphological changes were assessed using H&E staining and transmission electron microscopy (TEM).
Histidine-trytophan-ketoglutarate cardioplegia reduces inflammatory response and serum levels of myocardial enzymes in newly developed right-thoracotomy rat model.
Sci Rep
October 2024
Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, No. 123, Tianfei Lane, Mochou Road, Nanjing, 210004, Jiangsu, China.
Article Synopsis
- The research aimed to create a practical and cost-effective rat model for cardiopulmonary bypass (CPB) that simulates clinical cardiac surgery, focusing on cardiac arrest and resuscitation.
- Thirty rats were divided into three groups receiving different types of cardioplegia: histidine-tryptophan-ketoglutarate (HTK), blood cardioplegia (BC), and del Nido (DN), with the CPB procedure lasting one hour followed by observation.
- Results showed that HTK cardioplegia led to lower histopathological scores and reduced inflammatory response compared to BC and DN groups, suggesting it may protect the heart more effectively during CPB.
Pain perception during intravitreal injections is related to the timing of instilling anesthetic eyedrops.
Int Ophthalmol
September 2024
Ophthalmology Department, Shaare Zedek Medical Center, Jerusalem, Israel.
Purpose: To evaluate the correlation between the timing of instilling anesthetic eyedrops prior to intravitreal injection and the patient's perception of pain associated with the injection.
Methods: A prospective observational study which included 192 eyes of 192 patients. Time interval between instillation of Oxybuprocaine-0.
Local anaesthetic to reduce injection pain in patients who are prescribed intramuscular benzathine penicillin G: a systematic review and meta-analysis.
EClinicalMedicine
October 2024
Institute of Health Informatics Research, University College London, London, UK.
Article Synopsis
- Prolonged intramuscular injections of benzathine penicillin G (BPG) are essential for preventing group A streptococcal infections and reducing the risk of rheumatic fever and heart disease, but the pain from these injections may reduce patient compliance.
- * This systematic review and meta-analysis aimed to evaluate the effectiveness of local anaesthetics in reducing pain associated with BPG injections by analyzing randomised controlled trials comparing BPG alone to BPG with anaesthetics.
- * Out of 3958 records, eight trials with 489 patients were included, revealing that while patients reported high levels of immediate pain, some still experienced low-intensity pain 24 hours later.
Mitigating Cold Ischemic Injury: HTK, UW and IGL-2 Solution's Role in Enhancing Antioxidant Defence and Reducing Inflammation in Steatotic Livers.
Int J Mol Sci
August 2024
Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain.
Liver transplantation remains the only definitive treatment for end-stage liver diseases. However, the increasing prevalence of fatty liver disease among potential donors exacerbates the shortage of suitable organs. This study evaluates the efficacy of the preservation solution Institut Georges Lopez-2 (IGL-2) compared to Histidine-Tryptophan-Ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions in mitigating ischemia-reperfusion injury (IRI) in steatotic livers.
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