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Circulating Baseline CXCR3Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis.
ACR Open Rheumatol
January 2025
University of Gothenburg, Gothenburg, Sweden.
Objective: The high prevalence of osteoporosis in rheumatoid arthritis (RA) is due to inflammation that stimulates differentiation of osteoclasts, a process involving circulating monocytes and T cell-derived factors. The aim of this study was to evaluate relations between circulating monocytes, T cell subsets, and changes in bone characteristics before and after treatment with biological disease-modifying antirheumatic drugs (bDMARDs) in RA.
Methods: Thirty patients with untreated early RA who met the American College of Rheumatology/EULAR 2010 criteria were included.
Development of analytical equations for void fraction in biphasic systems using gamma radiation and MCNP6 code.
Appl Radiat Isot
December 2024
Instituto de Engenharia Nuclear - (IEN), Rua Hélio de Almeida 75, 21941-906, Cidade Universitária, RJ, Brazil. Electronic address:
This study presents the development of mathematical equations for calculating void fractions in pipes using gamma densitometry. A traditional measurement setup, consisting of aCs point source and a NaI(Tl) scintillator detector, was simulated using the Monte Carlo method via the MCNP6 code. To validate the proposed equations, water-gas biphasic models were simulated in tubes with square and cylindrical cross-sections, varying diameters, and radiation sources (Am, Cs, Co) through gamma-ray transmission.
View Article and Find Full Text PDFDapagliflozin cardiovascular effects on end-stage kidney disease (DARE-ESKD-2) trial: rationale and design.
Expert Opin Drug Saf
October 2024
Laboratory of Atherosclerosis and Vascular Biology (Aterolab), Faculty of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil.
Article Synopsis
- Dapagliflozin is being studied for its potential to improve heart function in patients with chronic kidney disease, and this research seeks to see if it has similar benefits for those on dialysis.
- The DARE-ESKD-2 trial involves adults on dialysis for over three months and randomly assigns them to receive either dapagliflozin or standard treatment for 24 weeks, measuring various heart function indicators.
- With 80 patients enrolled, the trial aims to gather new insights on how SGLT2 inhibitors like dapagliflozin could be beneficial for patients with end-stage kidney disease undergoing dialysis.
Vertebral marrow fat fraction is associated with circulating RANKL in postmenopausal females.
Front Endocrinol (Lausanne)
October 2024
Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Objective: To investigate the relationship between circulating receptor activator of nuclear factor-kappa B ligand (RANKL) levels and marrow adipose tissue in postmenopausal females.
Methods: A total of 164 postmenopausal females were included in the study. Serum levels of osteoprotegerin (OPG) and RANKL were measured using ELISA kits.
Quantitative Aortography Analysis of JenaValve's Trilogy Transcatheter Aortic Valve Implantation System in Patients With Aortic Regurgitation or Stenosis.
Struct Heart
September 2024
CORRIB Research Centre for Advanced Imaging and Core Laboratory, University of Galway, Galway, Ireland.
Background: JenaValve's Trilogy transcatheter heart valve (THV) (JenaValve Inc, Irvine, CA) is the only -marked THV system for the treatment of aortic regurgitation (AR) or aortic stenosis (AS). However, its efficacy has not been quantitatively investigated pre- and post-implantation using video-densitometric analysis.
Methods: Using the CAAS-A-Valve 2.
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