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CLINICAL EFFICACY OF ORAL AZITHROMYCIN VERSUS OTHER ANTIMICROBIAL DRUGS IN THE TREATMENT OF TYPHOID PATIENTS ACROSS ALL AGE GROUPS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS.
J Ayub Med Coll Abbottabad
December 2024
Federal Medical College, Islamabad-Pakistan.
Background: Typhoid is a major health concern. Drug-resistant cases of typhoid have given rise to new debates. Azithromycin has shown adequate results.
View Article and Find Full Text PDFNon-typhoidal in humans in India, Vietnam, Bangladesh and Sri Lanka: a systematic review.
JAC Antimicrob Resist
December 2024
Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.
Objectives: Non-typhoidal (NTS) commonly causes a self-limiting illness but invasive disease (iNTS) can be life-threatening. Antimicrobial resistance (AMR) increases the risk of mortality. This systematic review aimed to estimate the proportion of NTS isolated in those attending healthcare services, serovar burden, AMR, serovar-specific AMR, and case fatality rate (CFR) in India, Bangladesh, Sri Lanka and Vietnam.
View Article and Find Full Text PDFSerovars, virulence factors, and antimicrobial resistance profile of non-typhoidal Salmonella in the human-dairy interface in Northwest Ethiopia: A one health approach.
PLoS Negl Trop Dis
November 2024
Department of Medical Microbiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Article Synopsis
- * In a study conducted in Northwest Ethiopia from June 2022 to August 2023 across 58 dairy farms, 362 samples were tested for NTS, resulting in detection of 28 isolates (7.7%), with S. Uganda being the most prevalent serovar.
- * The study found that 100% of NTS isolates had the invA virulence gene, 21.4% had spvC, and a high proportion (89.3%) were resistant to at least
Association of Sickle Cell Disease, Malaria and HIV in Multi Drug Resistant Invasive Non-typhoidal Isolated from Outpatient and Hospitalised Children Below 16 Years in Informal Settlements in Nairobi County, Kenya.
East Afr Sci
January 2024
Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Background: Invasive non-typhoidal (iNTS) disease continues to be a major public health problem, especially in sub-Saharan Africa (SSA), where incidence rates are 227 cases [range 152-341] per 100,000 populations. Populations at risk of iNTS include adults with human immunodeficiency virus (HIV) infection, malnourished children, and those with recent malaria or sickle-cell anaemia (SCA). In Kenya, iNTS disease is particularly a major challenge in poor informal settlements, with infants and young children less than 5 years of age being the most affected.
View Article and Find Full Text PDFPrevalence of Salmonella Typhi, its associated factors and antimicrobial susceptibility profile among patients attending Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia.
BMC Infect Dis
October 2024
School of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.
Article Synopsis
- * Significant risk factors associated with S. Typhi infection include not washing hands before meals, eating raw vegetables, and drinking stream water, indicating potential prevention measures.
- * The bacteria showed high susceptibility to antibiotics with 90% effective response to ciprofloxacin, and 80% efficacy to ceftriaxone and chloramphenicol, suggesting these treatments could be effective choices for managing infections.
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