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Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo.
Parasit Vectors
December 2024
Laboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, 030801, People's Republic of China.
Article Synopsis
- Toxoplasma gondii is a common parasite in warm-blooded animals and humans, with current treatments like pyrimethamine and sulfadiazine having significant limitations, prompting a search for safer, more effective options.
- This study focused on glabridin, a natural compound from a medicinal plant, finding it to be low in toxicity while effectively inhibiting T. gondii growth and altering its structure.
- The results showed that glabridin improved survival rates in infected mice and affected T. gondii's metabolism, suggesting a promising new treatment avenue for this parasite.
Dynamic interaction of antibiotic resistance between plant microbiome and organic fertilizers: sources, dissemination, and health risks.
World J Microbiol Biotechnol
December 2024
Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Antibiotic resistance is a global health problem driven by the irrational use of antibiotics in different areas (such as agriculture, animal farming, and human healthcare). Sub-lethal concentrations of antibiotic residues impose selective pressure on environmental, plant-associated, and human microbiome leading to the emergence of antibiotic-resistant bacteria (ARB). This review summarizes all sources of antibiotic resistance in agricultural soils (including manure, sewage sludge, wastewater, hospitals/pharmaceutical industry, and bioinoculants).
View Article and Find Full Text PDFHealing Effect of in Burn Injuries.
World J Plast Surg
January 2024
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Burn injury is still the leading cause of mortality and morbidity in burn patients. We comapred healing effect of , silver sulfadiazine and alpha ointments on burn injuries in rat model.
Methods: Sixty female Sprague-Dawley rats in an animal experimental study were randomly divided to 5 equal groups as , silver sulfadiazine and (SSD), alpha, gel base and the burn injury left untreated.
Topical application of anti-inflammatory agents on burn wounds and their effect on healing.
Burns
December 2024
United States Army Institute of Surgical Research, Fort Sam Houston, TX, United States. Electronic address:
Advancements in the treatment of burns have considerably improved overall survival rates, but they have also highlighted several long-term sequelae related to the injury. Hypertrophic scars can impair function, reduce quality of life, and require multiple procedures as well as physical therapy. The purpose of this study was to investigate the effects of topical application of anti-inflammatory drugs in the treatment of burns.
View Article and Find Full Text PDFEvaluation of nitazoxanide in the treatment of experimental murine neurotoxoplasmosis.
Rev Inst Med Trop Sao Paulo
October 2024
Universidade Federal de Jataí, Instituto de Ciências da Saúde, Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Jataí, Goiás, Brazil.
Article Synopsis
- Toxoplasmosis is a common zoonotic disease that poses serious global health risks, particularly neurotoxoplasmosis, which has a high mortality rate.
- This study tested the effectiveness of nitazoxanide on mice infected with neurotoxoplasmosis, comparing it to the standard treatment of pyrimethamine plus sulfadiazine.
- Results showed that while nitazoxanide reduced parasitic load and had similar toxicity to standard treatment, it was less effective overall, making pyrimethamine and sulfadiazine the preferred option for treating this condition.
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