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Medullary Thyroid Carcinoma in the Background of Non-neoplastic Toxic Nodular Goiter.
AACE Clin Case Rep
September 2024
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
Background/objective: Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer (TC), rarely found in hyperfunctioning goiter.
Case Report: We present a case of a woman treated for breast carcinoma (BCA) found to have a benign hyperfunctioning nodular goiter, its likely transformation to MTC, and its treatment. Family history revealed papillary thyroid cancer in her nephew.
A Case Report of an Osteolytic Mass Hiding Behind an Undiagnosed Parathyroid Adenoma.
Cureus
November 2024
Maxillofacial Surgery, King Hussein Medical Center, Amman, JOR.
Hyperparathyroidism is a common endocrinopathy classified into three subtypes: primary, secondary, and tertiary. One of the rare symptoms that patients with hyperparathyroidism present is the formation of osteolytic lesions of the jaws. Brown tumors are rare skeletal osteolytic masses of a poorly understood etiology.
View Article and Find Full Text PDFFugitive Acromegaly: A Historical, Clinical, and Translational Perspective.
Front Horm Res
November 2024
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center - Tufts University School of Medicine, Boston, Massachusetts, USA.
The term 'fugitive acromegaly' was introduced by the neurosurgeons Bailey and Cushing in 1928 to describe subjects manifesting signs and symptoms of somatotroph hyperfunction with pituitary insufficiency. Currently, it identifies patients with subtle acromegalic dysmorphisms and inconsistent hormonal profile, possibly presenting only with hyperprolactinemia and related clinical symptoms. Patients have rapidly growing, locally invasive, relapsing pituitary macrotumors that can be classified as either acidophil stem cell tumors (ASCTs) or sparsely granulated somatotroph tumors (SGSTs), both of PIT1-lineage.
View Article and Find Full Text PDFAdrenocortical Carcinoma: A Challenging Diagnosis.
Cureus
October 2024
Internal Medicine, Unidade Local de Saúde Viseu Dão-Lafões, Viseu, PRT.
Adrenocortical carcinoma (ACC) is a rare malignancy with aggressive behaviour and a poor prognosis. Patients can present with adrenal hormonal excess or with nonspecific symptoms driven by the presence of an abdominal mass or metastatic disease. Many are completely asymptomatic and diagnosed incidentally.
View Article and Find Full Text PDFSurgical versus non-surgical management of hyperfunctional thyroid metastasis: a case report.
J Med Case Rep
November 2024
Department of General Surgery, Subdivision of Surgical Oncology, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Dr. Qarib St, Keshavarz Blvd, P.O Box: 1419733141, Tehran, Iran.
Background: Hyperthyroidism, caused by metastatic differentiated thyroid cancer, is a rare condition that can be difficult to diagnose. Thyrotoxicosis and metastatic disease regarding functional metastasis increase morbidity and mortality in patients with functional metastasis and need to be treated. This study aims to present a case of hyper-functional metastasis of thyroid cancer to analyze its pathological features, diagnostic procedures, and treatment options and to gather and examine recent cases of hyper-functional metastasis of thyroid cancer.
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