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Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma.
Mol Cell Biol
December 2024
Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
In esophageal squamous cell carcinoma, genetic activation of NRF2 increases resistance to chemotherapy and radiotherapy, which results in a significantly worse prognosis for patients. Therefore NRF2-activated cancers create an urgent clinical need to identify new therapeutic options. In this context, we previously identified the geldanamycin family of HSP90 inhibitors, which includes 17DMAG, to be synthetic lethal with NRF2 activity.
View Article and Find Full Text PDFPlasmapheresis for extracorporeal membrane oxygenation (ECMO)-induced hemolysis in infants.
J Extra Corpor Technol
December 2024
Division of Pediatric Nephrology, Joe DiMaggio Children's Hospital, 1131 N35th Ave, Hollywood, FL 33021, USA - Charles E. Schmidt College of Medicine at Florida Atlantic University, 777 Glades Rd BC-71, Boca Raton, FL 33431, USA.
Background: Intravascular hemolysis is a known complication of extracorporeal membrane oxygenation (ECMO). Characterized by elevated plasma-free hemoglobin (PFH), intravascular hemolysis is associated with cytotoxic effects leading to renal replacement therapy (RRT), longer ECMO runs, and mortality. Therapeutic plasma exchange (TPE) in tandem with ECMO was described as a therapy for various pathologic conditions, but there are no Extracorporeal Life Support Organization (ELSO) guidelines for the treatment of ECMO-induced hemolysis.
View Article and Find Full Text PDFEpilepsy surgery in children with operculoinsular epilepsy: Results of a large unicentric cohort.
Epilepsia
December 2024
Department of Paediatric Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Objective: Epilepsy surgery in the operculoinsular cortex is challenging due to the difficult delineation of the epileptogenic zone and the high risk of postoperative deficits.
Methods: Pre- and postsurgical data from 30 pediatric patients who underwent operculoinsular cortex surgery at the Motol Epilepsy Center Prague from 2010 to 2022 were analyzed.
Results: Focal cortical dysplasia (FCD; n = 15, 50%) was the predominant cause of epilepsy, followed by epilepsy-associated tumors (n = 5, 17%) and tuberous sclerosis complex (n = 2, 7%).
Forage, freedom of movement, and social interactions remain essential fundamentals for the welfare of high-level sport horses.
Front Vet Sci
November 2024
INRAE, CNRS, Université de Tours, PRC, Nouzilly, France.
Article Synopsis
- Societal concerns about animal welfare now include high-level sport horses, especially highlighted during recent Olympics, leading to public inquiries about their living conditions.
- Animal welfare studies emphasize the "3Fs" for equine welfare: access to forage, freedom of movement, and social interactions, but the challenges for sport horses in meeting these needs are not well understood.
- A field study assessing 56 high-level sport horses found significant variability in access to the "3Fs," showing that those with fewer restrictions had better welfare outcomes.
Background: As bronchiectasis progresses, increasing degrees of airflow limitation can occur.
Objectives: This study aimed to investigate whether concomitant airflow limitation was associated with poor prognosis in patients with bronchiectasis and to identify the characteristics of patients with airflow limitation in bronchiectasis.
Design: A prospective longitudinal study was conducted to determine the characteristics and prognosis of bronchiectasis patients with airflow limitation.
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